p120ctn 和 Her －2在 ER、PR 阴性乳腺癌组织中的表达及临床意义

目的：探讨连环蛋白 p120（p120ctn）和人表皮生长因子受体－2（Her －2）在 ER、PR 阴性乳腺癌组织中的表达情况及其与临床病理特征的关系。方法：用免疫组化方法检测87例雌激素受体（ER）、孕激素受体（PR）阴性乳腺癌组织及其中41例癌旁乳腺组织和33例乳腺纤维腺瘤组织中 Her －2及 p120ctn 的表达情况。结果：87例 ER、PR 阴性乳腺癌组织中 p120ctn 蛋白在细胞膜异常表达率为63．2％（55／87），Her －2阳性表达为60．9％（53／87）。41例癌旁乳腺组织中 p120ctn 蛋白在细胞膜异常表达率为7．3％（3／41），Her －2无阳性表达；33例乳腺纤维腺瘤组织中 p120ctn 异常表达率为9．1％（3／33），Her －2亦无阳性表达。p120ctn 异常表达、Her －2阳性表达在 ER、PR 阴性乳腺癌组织与癌旁乳腺组织、乳腺纤维腺瘤组织中差异显著（P ＝0．000）。p120ctn 的异常表达和 Her －2的阳性表达与癌组织的组织学分级和淋巴结转移均显著相关（P＜0．05），与患者的月经、年龄、肿瘤大小和临床分期无关（P ＞0．05）。p120ctn 的异常表达和 Her －2的阳性表达在 ER、PR 阴性乳腺癌组织中呈显著正相关关系（r ＝0．952，P ＝0．000）。结论：p120ctn 的异常表达和Her －2阳性表达在 ER、PR 阴性乳腺癌的发生、发展中可能起到协同作用。联合检测对评估预后以及为基因靶向治疗提供初步依据。

Expression and clinical significance of p120ctn and Her -2 in ER and PR negative breast carcinoma tissues

Objective:To investigate in vivo expression of p120ctn and Her -2 in breast carcinoma with negative ER,PR and analyze its relationship with pathological characteristics.Methods:Immunohistochemical method was per-formed to detect expression of p120ctn and Her -2 in tissues from 87 cases of breast carcinoma with negative ER, PR,41 cases of paraneoplastic breast tissues and 33 cases of breast adenofibroma.Results:The rates of p120ctn aber-rant expression and Her -2 positive were 63.2% and 60.9%,respectively in 87 cases with negative ER and PR breast carcinoma,with 7.3% and 0% in 41 cases of paraneoplastic breast tissues and 9.1% and 0% in 33 cases of breast adenofibroma.The significant differences were seen among the aberrant expression of p120ctn and Her -2 posi-tive in ER and PR negative breast carcinoma compared with that of paraneoplastic breast tissues and breast adenofi-broma (P =0.000).Aberrent expression of p120ctn and Her -2 positive with ER,PR negative breast carcinoma were closely associated with histological grade and lymph node metastasis(P <0.05),but not related with the age,men-struation,tumor size and clinical stages(P >0.05).Furthermore,the aberrant expression of p120ctn was correlated with Her -2 positive in ER and PR negative breast carcinoma (r =0.952,P =0.000).Conclusion:The aberrant expression of p120ctn and Her -2 positive are likely to have synergistic or related effect in the genesis and progres-sion of ER and PR negative breast carcinoma.Combined detection of p120ctn and Her -2 may offer the initial evi-dence for predicting prognosis and gene targeting therapy of ER,PR negative breast carcinoma.