| 自噬的表观遗传修饰在肿瘤发生发展中的作用 |
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| 引用本文： | 谢金芳,张泽兵. 自噬的表观遗传修饰在肿瘤发生发展中的作用[J]. 现代肿瘤医学, 2016, 0(13): 2156-2159. DOI: 10.3969/j.issn.1672-4992.2016.13.040 |
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| 作者姓名： | 谢金芳 张泽兵 |
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| 作者单位： | 吉林大学口腔医学院，吉林省牙发育及颌骨重塑与再生重点实验室，吉林 长春 130021 |
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| 基金项目： | 吉林省科技厅自然基金项目(编号20150101174JC)；吉林省卫生厅课题(编号20132004) |
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| 摘 要： | 细胞自噬是一种进化上的保守过程，可降解胞质成分从而促进细胞存活和组织平衡，它的激活与生物学功能受到多种自噬相关基因和信号通路的调节。其中表观遗传修饰广泛参与细胞自噬过程，调节细胞凋亡和自噬，成为癌症的另一种标志，在肿瘤的发生、发展中发挥了重要作用。为了更深入了解自噬的表观遗传修饰与肿瘤发生、发展的关系，本文将近期相关的研究进展做一综述。
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| 关 键 词： | 自噬 肿瘤 表观遗传学 |
The role of epigenetic modifications on autophagy in tumor |
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| Xie Jinfang,Zhang Zebing. The role of epigenetic modifications on autophagy in tumor[J]. Journal of Modern Oncology, 2016, 0(13): 2156-2159. DOI: 10.3969/j.issn.1672-4992.2016.13.040 |
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| Authors: | Xie Jinfang Zhang Zebing |
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| Affiliation: | School and Hospital of Stomatology，Jilin University，Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling，Jilin Changchun 130021，China. |
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| Abstract: | Autophagy is an evolutionarily conserved process that degrades cytoplasmic components,thus contributing to cell survival and tissue homeostasis.The progress of autophagy is regulated by many autophagey related genes and signaling pathways.As another marker of tumor,epigenetic modifications perform an extraordinarily vital function in the initiation and progression of tumor by regulating cell apoptosis and autophagy.More recent studies showed that theoccurrence and development of autophagy in tumor also involves a variety of epigenetic modifications.This review aimed to elaborate the effect of epigenetic modifications on the autophagy in tumors. |
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| Keywords: | autophagy neoplasm epigenetics |
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