66例广泛期小细胞肺癌患者预后分析

目的:分析广泛期小细胞肺癌的独立预后因素。方法:回顾性分析安阳市肿瘤医院2005年7月至2009年7月治疗的66例广泛期小细胞肺癌的临床资料，所有患者均经组织病理或细胞学确诊。生存分析采用Kaplan-Meier法计算生存率，Log-rank检验进行单因素分析，并对有意义的单因素通过COX风险模型筛选影响预后因素。结果:广泛期患者1、2、3年生存率分别为40.9%、13.6%、6.1%，中位生存时间为10个月。单因素分析显示体重减轻情况、一线化疗疗效、总化疗周期数、治疗方式、低钠血症与患者预后相关，具有统计学差异。多因素分析显示一线化疗疗效、总化疗周期数、低钠血症对患者的总生存时间具有显著影响。结论:一线化疗疗效、总化疗周期数和低钠血症是影响广泛期小细胞肺癌的独立预后因素。

Prognostic factors for the survival of 66 cases with extensive stage small cell lung cancer

Objective:To investigate prognostic factors associated with survival of patients with extensive stage small cell lung cancer（ES-SCLC).Methods:Clinical data from 66 cases with ES-SCLC diagnosed through histopathology or cytology between July 2005 and July 2009 were analyzed.Kaplan-Meier，Log-rank test and COX proportional hazards regression analysis were preformed to make univariate and multivariate analysis.Results:The 1，2,3-year survival rates were 40.9%，13.6% and 6.1% respectively.The median survival time(MST ) was 10 months.Univariate analyses indicated that weight loss，efficacy of first-line chemotherapy，the total number of cycles of chemotherapy，treatment method，serum sodium were significantly influenced survival of ES-SCLC.The multivaeiate analyses suggested that efficacy of first-line chemotherapy，the total number of cycles of chemotherapy，and serum sodium were independent prognostic factors of survival.Conclusion:The efficacy of first-line chemotherapy，the total number of cycles of chemotherapy，and serum sodium are important prognostic factors for patients with ES-SCLC.