膜联蛋白 A2在子宫内膜癌组织中的表达及临床意义

目的：检测膜联蛋白（annexin A2，ANXA2）在子宫内膜癌中的表达情况，探讨 ANXA2表达与子宫内膜癌临床病理参数的关系及临床意义。方法：采用免疫组化 SP 法检测76例子宫内膜癌、27例非典型增生子宫内膜及16例正常子宫内膜中 ANXA2的表达情况，并分析其与子宫内膜癌临床病理参数及预后的关系。结果：ANXA2在子宫内膜癌组（96.1%）和非典型增生组（96.3%）的阳性率明显高于正常子宫内膜组（62.5%）（P 均<0.05）。ANXA2表达随着 FIGO 分期增加、分化程度减低而逐渐增加（P <0.05），ER、PR 阴性组 ANXA2阳性率（均为100.0%）明显高于阳性组（分别为87.5%，88.0%）（P 均<0.05），而淋巴结转移阳性组 ANXA2高表达率（93.8%）明显高于淋巴结转移阴性组（60.0%）（P <0.05）。ANXA2低表达组子宫内膜癌患者预后更佳（P <0.05）。结论：ANXA2在子宫内膜癌组织中的表达明显增高，ANXA2可监测子宫内膜癌患者预后。

The expression and clinical significance of annexin A2 in endometrial carcinoma

Objective:To explore the relationship between expression of annexin A2(ANXA2)and clinicopatho-logical parameters and the clinical significance of annexin A2 by detecting the expression of annexin A2 in different endometrial tissues. Methods:Expression of ANXA2 in 76 endometrial carcinoma,27 atypical hyperplasia endometri-um,16 cases of normal endometrium was detected by immunohistochemistry,and the relationship between ANXA2 ex-pression and clinicopathological parameters in endometrial carcinoma was analyzed. Results:The expression levels of ANXA2 in endometrial carcinoma and atypical hyperplasia(96. 1% ,96. 3% )were significantly higher than normal endometrium(62. 5% )(both P < 0. 05). ANXA2 expression was increased with FIGO stage progression and the de-creasing of differentiation degree. The positive expression rates of ANXA2 in ER( - )and PR( - )group(both were 100. 0% )were significantly higher than that of ER( + )and PR( + )groups(87. 5% ,88. 0% ,respectively, both P < 0. 05). Strong expression rate of ANXA2 was significantly higher in lymph metastasis( + )(93. 8% )than in lymph metastasis( - )group(60. 0% )(P < 0. 05). Higher ANXA2 expression level could predict a poor progno-sis(P < 0. 05). Conclusion:The expression level of ANXA2 was significantly increased in endometrial carcinoma and could predict poor prognosis of endometrial carcinoma patients.