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| 肿瘤相关基因NET-1的研究进展 | |
| 引用本文： | 顾婷婷,陈莉. 肿瘤相关基因NET-1的研究进展[J]. 现代肿瘤医学, 2016, 0(12): 1999-2002. DOI: 10.3969/j.issn.1672-4992.2016.12.045 |
| 作者姓名： | 顾婷婷 陈莉 |
| 作者单位： | 南通大学医学院病理学系，江苏 南通 226001 |
| 基金项目： | 江苏省产学研前瞻性联合研究项目(BY2013042-06) |
| 摘 要： | NET-1(tspan1)是新近被证实的四次跨膜蛋白超家族(transmembrane 4 superfamily,TM4SF)的成员之一。作为一种肿瘤相关基因，与肿瘤细胞的增殖、迁移、内吞作用和诱导血管形成密切相关。NET-1蛋白的异常表达可能是引起和维持癌恶性表型的原因之一，其表达水平对癌的预后具有评估价值，该基因可能成为肿瘤基因治疗的靶点。 |
| 关 键 词： | NET-1 肿瘤 RNA干扰 miRNA |
Progress of NET-1 gene in tumors |
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| Gu Tingting,Chen Li. Progress of NET-1 gene in tumors[J]. Journal of Modern Oncology, 2016, 0(12): 1999-2002. DOI: 10.3969/j.issn.1672-4992.2016.12.045 | |
| Authors: | Gu Tingting Chen Li |
| Affiliation: | Department of Pathological Anatomy,Nantong University,Jiangsu Nantong 226001,China. |
| Abstract: | As a tumor related gene of the recently confirmed members of transmembrane 4 superfamily (TM4SF),NET-1 (tspan1) is closely associated with cell proliferation,migration,endocytosis and angiogenesis of tumor cells.The abnormal expression of NET-1 gene may be involved in the initiation and progress of the malignant phenotype.NET-1 may be the key to the target gene therapy for cancer,and becomes a promising biomarker for the severity of tumor diseases. |
| Keywords: | NET-1 tumor RNA interfering miRNA |
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