瘤相关易栓症炎症因子表达与凝血功能的相关性

目的:探讨瘤相关易栓症炎症因子表达与凝血功能的相关性。方法:回顾性分析2011年1月-2013年4月共72例肿瘤患者临床资料，探讨其炎症因子（IL-1β、IL-18和TNF-α）和凝血指标（PT、APTT、TF和CP）的相关性。结果:急性白血病、非霍奇金淋巴瘤、肺癌治疗前后，凝血功能指标（PT、APTT、TF和CP）和炎症因子（IL-1β、IL-18和TNF-α）比较，差异有统计学意义（P<0.05）；对照组与急性白血病、非霍奇金淋巴瘤、肺癌治疗后的以上指标比较，差异有统计学意义（P<0.05）。TF和IL-1β、IL-18、TNF-α，CP和TNF-α存在明显相关性（P<0.05）；而CP和IL-1β、IL-18则无相关性（P>0.05）。结论:瘤相关易栓症中炎症因子（IL-1β、CP和IL-18）及凝血指标（PT、APTT、TF和CP）均呈高表达性，炎症因子促进TF和CP表达，造成凝血功能紊乱。

Correlation of tumor -related thrombophilia expression of inflammatory cytokines and coagulation function

Objective:To investigate the tumor -associated thrombophilia expression of inflammatory cytokines and coagulation relevance.Methods:A retrospective analysis of 72 cancer patients was performed,observe its rele-vance in the inflammatory cytokines IL -1β,IL -18 and TNF -αand coagulation PT,APTT clotting.Results:The treatment of acute leukemia,non -Hodgkin's lymphoma,lung cancer in coagulation parameters PT,APTT,TF,CP and inflammatory cytokines IL -1β,IL -18,TNF -αdifference was statistically significant(P <0.05).Control group and the treatment of acute leukemia,non -Hodgkin's lymphoma,lung cancer index difference was statistically significant (P <0.05).TF and IL -1β,IL -18,TNF -α,CP and TNF -αwere significantly correlated(P <0.05).CP and IL-1β,CP and IL -18 had no correlation(P >0.05).Conclusion:The tumor -associated thrombophilia inflammatory cytokines IL -1β,CP and IL -18,coagulation PT,APTT,TF,CP showed a high expression of inflammatory factors promoting the expression of TF and CP,causing blood clotting disorders.