| 慢性粒细胞白血病相关抗原HLA-A2.1限制性CTL表位的生物信息学分析 |
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| 引用本文： | 付伟,王松,班春梅,谢东,罗永婧,梁英民. 慢性粒细胞白血病相关抗原HLA-A2.1限制性CTL表位的生物信息学分析[J]. 现代肿瘤医学, 2016, 0(8): 1175-1177. DOI: 10.3969/j.issn.1672-4992.2016.08.001 |
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| 作者姓名： | 付伟 王松 班春梅 谢东 罗永婧 梁英民 |
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| 作者单位： | 1. 解放军第四十四医院血液科,贵州贵阳,550009;2. 第四军医大学唐都医院血液科,陕西西安,710032 |
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| 基金项目： | 贵州省卫生计生委科学技术基金(gzwjkj2014-1-058) |
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| 摘 要： | 目的:预测慢性粒细胞白血病BCR/ABL融合基因HLA-A2.1限制性细胞毒性T细胞表位.方法:运用BIMAS、SYFPEITHI、Predep、Immune Epitope Database和Analysis Resource(IEDB)软件预测BCR/ABL融合基因可能的HLA-A2.1限制性CTL表位.结果:结合BIMAS、SYFPEITHI、Predep和IEDB预测BCR/ABL融合基因的HLA-A2.1限制性CTL表位,共6条.结论:综合运用多个预测软件可提高预测效率获得目的表位肽,为下一步基础实验打下基础.
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| 关 键 词： | 慢性粒细胞白血病 BCR/ABL CTL表位 |
Prediction of HLA-A2 . 1-restricted CTL epitope derived from tumor antigens associated with chronic myeloid leukemia |
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| Abstract: | Objective:Prediciting the HLA-A2. 1-restricted CTL epitopes derived from chronic myeloid leuke-mia BCR/ABL fusion protein. Methods:The HLA-A2. 1 restricted CTL epitope of the BCR/ABL fusion protein were predicated by BIMAS,SYFPEITHI,Predep and IEDB methods. Results:Six HLA-A2. 1 restricted CTL epitopes de-rived from BCR/ABL fusion protein were predicted according to the methods of BIMAS,SYFPEITHI,Predep and IEDB. Conclusion:Synthetical prediction methods can offer the efficiency in predicting the HLA-A2. 1 restricted CTL epitopes of BCR/ABL fusion protein. |
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| Keywords: | chronic myeloid leukemia BCR/ABL CTL epitope |
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