干扰素治疗急性轮状病毒肠炎临床疗效观察

目的观察干扰素(IFN)治疗轮状病毒肠炎的.临床疗效.方法将163例轮状病毒肠炎患儿随机分成2组,对照组74例,予思密达保护胃肠黏膜、促菌生调节肠道微生态、纠正水电解质及酸碱平衡紊乱等治疗,治疗组89例,在上述治疗基础上,予肌注重组人干扰素α1b 8万u/kg,1次/d×5d.结果干扰素组退热时间、腹泻持续天数、呕吐症状消失时间和静脉补液所需天数,均比对照组明显缩短(P＜0.05);脱水纠正所用时间比对照组短,但两组间比较无明显差异(P＞0.05).结论α-干扰素治疗轮状病毒肠炎虽然不能缩短脱水纠正所需时间,但可明显改善症状、缩短病程,治疗有效,有临床实用价值,而且安全可行.

Therapeutic effect of interferon on acute rotavirus enteritis

Objective: To observe the therapeutic effect of interferon on rotavirus diarrhea disease. Methods: 163 cases of children with rotavirus enteritis randomly were divided into 2 groups: 74 cases of control group treated with smectite of mucosal barrier protectant, cerebiogen of modulation gastrointestinal microecosystem, correction of modulation gastrointestinal microecosystem, correction eletrolyte and acid-alkali balance turbulence, and diet without lactose. 89 cases of treatment group had the same therapeutic regimens, and in addition to recombinant human interferon a1b injection (80.000 units/kg IM, one time a day for 5 days). Results: The defervesce time, days of vomit, diarrhea days and days of infusion by vein in interferon treatment group all were shorter than those in control group (P <0.05); the redress desiccation time in treatment group was shorter, but there was not signififcantly difference between two groups. Conclusion: Interferon is safe and efficient in treating acute rotavirus enteritis. It can effectively improve the symptom and reduce course of disease with rotavirus enteritis.