生脉散对急性心肌梗塞患者的抗脂质过氧化作用

本文探讨了３０例心绞痛和６８例急性心肌梗塞（ＡＭＩ）患者与脂质过氧化损伤的关系，并观察了中药生脉散颗粒剂对ＡＭＩ患者的抗脂质的过氧化作用。发现冠心病（ＣＨＤ）患者较健康人血中超氧化物歧化酶（ＳＯＤ），谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显降低，而丙二醛（ＭＤＡ）显著升高（Ｐ＜０．００１）。当给ＡＭＩ患者口服生脉散颗粒９ｇ／ｄ２周，血中ＳＯＤ和ＧＳＨ－Ｐｘ明显升高，ＭＤＡ显著降低（Ｐ＜０．０５）

Effect of Sheng Mai San on Lipid Peroxidation in Acute Myocardial Infarction Patients

The effect of Sheng Mai San(SMS) on the coronary heart disease(CHD) patients (30 angina pectoris and 68 acute myocardial infartion, AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in blood were decreased and the content of malondialdehyde(MDA) in plasma was increased in CHD patients in comparison with the healthy controls(P<0.001). When SMS was orally administered in 38 AMI patients, both SOD and GSH-Px activities were increased and the level of MDA decreased (P< 0.05), and these changes were even more significant when SMS was further ingested for another two weeks(P<0.001). At the same time, it was found that the changes of SOD, GSH-Px and MDA in the control group(30 AMI patients not taking SMS) were not significantly different(P>0.05). It could be assumed that the pathogenesis of CHD is associated with free redical(FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effective free radical scavenger, which would ameliorate the lipid peroxidation damage. Thus, SMS could be administered in the prevention and the treatment of CHD.