中西医结合治疗原发性肾病综合征及其对血液流变学的影响

对比观察了中西医结合治疗（治疗组）与单纯西药治疗（对照组）成人原发性肾病综合征的临床疗效及其与血液流变学的关系。结果表明，前者的临床缓解率及总有效率分别为６５．４％和８８．５％，后者分别为３７．０％和５９．３％，差异有显著性意义（Ｐ＜０．０１）；治疗组用激素的不良反应计分数显著低于对照组（Ｐ＜０．０１）；治疗组的复发率为７．２５％，对照组为５３．１３％（Ｐ＜０．０１）；在改善血液粘滞度和降低纤维蛋白原含量方面，治疗组作用显著。提示中医辨证论治配合激素，不仅能减少激素的不良反应，还能提高疗效，减少复发。在辨证的基础上加用活血化瘀药对改善血液粘滞度和纤维蛋白溶解系统功能障碍亦有良好的效应。

Study on Efficacy of Adult Primary Nephrotic Syndrome with TCM-WM Therapy and Its Hemorheologic Effects

The efficay of TCM-WM therapy in treating adult primary nephrotic syndrome in comparing with using Western medicine alone and its influence on patient's hemorheology was investigated.The results showed that with the therapy of combined therapy the clinical remission rate and total effective rate were 65.4% and 88.5%,while that of Western medicine alone were 37.0% and 59.3% respectively.There was significant difference between the above-mentioned two groups(P<0.01).Adverse effect scores with combined therapy were much lower than that of WM alone(P<0.01).The recurrence rate of the illness with TCM-WM and WM therapy were 7.25% and 53.13%respectively(P<0.01).Furthermore,the combined treatment of TCM-WM could remarkably improve the blood viscosity and reduce the content of fibrinogen.It was suggested that Syndrome Differentiation with the administration of steriod could not only ameliorate the adverse effects of steroid but promote the efficacy and reduce the recurrence of the disease.Besides,the addition of blood-activating and stasis-removing herbs could also improve the blood viscosity and the impaired fibrinolysis.