| 从HCV蛋白一级结构预测其C,E,NS5区的CD_4~ T细胞抗原位点 |
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| 引用本文： | 周红超,徐德忠,张鹏,闫永平,张景霞,李远贵,杜尊宪,李玲秀,梁国政.从HCV蛋白一级结构预测其C,E,NS5区的CD_4~ T细胞抗原位点[J].细胞与分子免疫学杂志,1997(3). |
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| 作者姓名： | 周红超 徐德忠 张鹏 闫永平 张景霞 李远贵 杜尊宪 李玲秀 梁国政 |
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| 作者单位： | 第四军医大学流行病学教研室，西安市传染病院 |
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| 摘 要： | 我们根据ＣＤ４＋Ｔ细胞识别抗原位点的物理化学和生物学特征，设计了一个具有查找两亲性螺旋状结构（ａｍｐｈｉｐａｔｈｉｃｈｅｌｉｘｓｔｒｕｃｔｕｒｅ）肽段功能的计算机程序。用该程序对ＨＣＶ－１型病毒Ｃ、Ｅ（Ｅ１、Ｅ２／ＮＳ１）、ＮＳ５蛋白一级结构进行分析，发现这些蛋白区存在ＣＤ４＋Ｔ细胞识别位点。此结果支持了ＣＤ４＋Ｔ细胞对ＨＣＶＣ，Ｅ，ＮＳ５区可发生增殖反应的结论。提示该程序可作为一种预测ＣＤ４＋Ｔ细胞识别ＨＣＶ抗原位点的方法。
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| 关 键 词： | CD_4~＋T细胞 丙型肝炎病毒 抗原位点 预测 |
Prediction of CD 4 T Cell Antigen Sites in C, E, and NS5 Regions from the Primary Structure of HCV Proteins |
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| Zhou Hongchao,Xu Dezhong,Zhang Peng,et al..Prediction of CD 4 T Cell Antigen Sites in C, E, and NS5 Regions from the Primary Structure of HCV Proteins[J].Journal of Cellular and Molecular Immunology,1997(3). |
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| Authors: | Zhou Hongchao Xu Dezhong Zhang Peng |
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| Abstract: | A computer programme with the function of finding amphipathic helix structure was written on the basis of physical, chemical and biological characters of antigen sites that can stimulate CD 4 T cell.Analysis of the hepatitis C virus (HCV 1) primary sequence of C, E, and NS5 regions showed that the CD 4 T cell antigen sites could be found in these regions. The findings were in agreement with the conclusion that C, E and NS5 proteins could activate CD 4 T cell in HCV patients. It indicates that our programme can be used to predict the CD 4 T cell antigen sites on HCV proteins. |
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| Keywords: | hepatitis C virus CD 4 T cell antigen site prediction |
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