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Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (<Emphasis Type="Italic">PARK2</Emphasis>) exon 1–12 dosage |
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| Authors: | Maria I Shadrina Elena V Semenova Petr A Slominsky Gulbahar H Bagyeva Sergei N Illarioshkin Irina I Ivanova-Smolenskaia Svetlana A Limborska |
| Institution: | (1) Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov sq, 123182 Moscow, Russia;(2) Department of Neurogenetics, Institute of Neurology, 80 Volokolamskoye Highway, 123367 Moscow, Russia |
| Abstract: | BackgroundOne of the causes of Parkinson's disease is mutations in the PARK2 gene. Deletions and duplications of single exons or exon groups account for a large proportion of the gene mutations. Direct detection of these mutations can be used for the diagnosis of Parkinson's disease. |
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