| 慢性淋巴细胞白血病发生高度恶性淋巴血液病转化2例报告并文献复习 |
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| 引用本文： | 邬仁华,向兵,谢莉萍,陈新传,刘霆.慢性淋巴细胞白血病发生高度恶性淋巴血液病转化2例报告并文献复习[J].华西医学,2006,21(3):502-503. |
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| 作者姓名： | 邬仁华 向兵 谢莉萍 陈新传 刘霆 |
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| 作者单位： | 四川大学华西医院血液科,四川成都,610041 |
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| 摘 要： | 目的:增加对慢性淋巴细胞白血病转化为高度恶性淋巴血液病的认识。方法:报道两例分别转化为霍奇金淋巴瘤(混合细胞型)和弥漫大B细胞淋巴瘤的慢性淋巴细胞白血病病例,并复习相关文献。结果和结论:慢性淋巴细胞白血病在疾病进展过程中可以向多种高度恶性淋巴血液肿瘤转化:弥漫大B细胞淋巴瘤,幼淋巴细胞白血病,急性淋巴细胞白血病或霍奇金淋巴瘤等,其中以弥漫大B细胞淋巴瘤(Richter’s综合征)最为常见;病程中还可以并发多发性骨髓瘤及黑色素瘤等其他实体肿瘤。慢性淋巴细胞白血病发生血液高度恶性转化或伴发第二肿瘤均作为本病预后不良的指标,治疗效果差,生存期较单纯慢性淋巴细胞白血病显著缩短。
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| 关 键 词： | 慢性淋巴细胞白细胞 转化 霍奇金淋巴瘤 |
| 文章编号： | 1002-0179(2006)03-0502-02 |
| 收稿时间： | 2005-11-04 |
| 修稿时间： | 2005年11月4日 |
Occurrence of Chronic Lymphocytic Leukemia(CLL) to Highly Aggressive Hematologic Malignancy and Review Literature |
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| WU Ren- hua, XIANG Bing, XIE Li- ping,et al..Occurrence of Chronic Lymphocytic Leukemia(CLL) to Highly Aggressive Hematologic Malignancy and Review Literature[J].West China Medical Journal,2006,21(3):502-503. |
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| Authors: | WU Ren- hua XIANG Bing XIE Li- ping |
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| Institution: | Hematology Department, West China Hospital, Sichuan University, Chengdu 610041, Chian |
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| Abstract: | Objective:To improve the understanding of chronic lymphocytic leukemia(CLL) who transformed to highly aggressive hematologic malignant tumors.Methods:Report two cases of CLL who transformed to Hodgkin's lymphoma and large B cell lymphoma respectively.Results:and Conclusion:CLL can transform to many kinds of highly aggressive malignant tumors.Richter's syndrome is the most common transformation of CLL,CLL can also transform to prolymphocytic leukemia,acute lymphocytic leukemia,Hodgkin's lymphoma,multiple myeloma and other none hematologic tumors.All these transformations have poorer prognosis and shorter survival expectance. |
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| Keywords: | Chronic Lymphocytic Leukemia Transformation Hodgkin's lymphoma |
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