异甘草酸镁在原发性肝癌术后行肝动脉化疗栓塞患者中的临床应用

目的观察异甘草酸镁在原发性肝癌术后行经皮肝动脉化疗栓塞（TACE）患者中的临床应用效果。方法对照组用阿拓莫兰等护肝药物治疗；实验组在用阿拓莫兰等护肝药物的基础上加用异甘草酸镁（天晴甘美）两组均在TACE术前3d～术后5d用药，并在TACE术前及其后第二天，第五天抽血检测肝功能；并记录两组患者TACE术后不良反应的发生率。结果实验组TACE术后不良反应发生率明显低于对照组（P〈0．05）；TACE术后第二天两组患者TBIL、ALT、AST等指标均高于术前（P〈0．05）；术后第五天实验组ALT、AST与术前比较无显著性差异（P〉0．05），而术后第五天对照组ALT、AST仍高于术前（P〈0．05）；两组方案对TACE术后肝细胞合成指标降低均无明显改善作用（P〉0．05）。结论异甘草酸镁对TACE引起的患者肝功能损害有显著的保护作用，并可减轻TACE副反应。

Clinic effect of Magnesium isoglycurrhizinate on the postoperative patients with primary hepatic carcinoma after transeatheter arterial chemoembolization

OBJECTIVE To osherve the clinic effect of Magnesium isoglycurrhizinate on the postoperative patients with primary hepatic carcinoma after transeatheter arterial chemoembolization（TACE）.METHODS 97 patients were divided into two groups： in the control group, the patients were used hepatiniea drugs; in the therapy group, the patients were infused 150rag Magnesium isoglycurrhizinate from Preoperative 3 day to 5th day after TACE operation. And the incidences of the adverse effect after TACE operation were memorized. RESULTS The incidences of the adverse effect from the therapy group was lower than that from the control group（P 〈 0.05） .The level of TBIL、ALT and AST on 2nd day after TACE operation were higher than that before TACE operation in the both two groups（P 〈 0.05）. The level of ALT, AST on 5th day after TACE operation were revivaled in the therapy group（P 〉0.05） .But the level of AI,T and AST in the control group on 5th day were higher than that before TACE operation（P 〈 0.05）. The index of the synthesis ability of hepatocyte were not improve in the therapy group（P 〉0.05）. CONCLUSION Magnesium isoglycurrhizinate can distinctly protect the liver function of the postoperative patients with primary hepatic carcinoma after TACE operation and prevent the occurrence of the adverse effect.