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MR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model
Authors:Mingqian Tan  Susan M Burden-Gulley  Wen Li  Xueming Wu  Daniel Lindner  Susann M Brady-Kalnay  Vikas Gulani  Zheng-Rong Lu
Institution:(1) Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, Room 427, 10900 Euclid Avenue, Cleveland, Ohio 44106-7207, USA;(2) Laboratory of Biomedical Material Engineering Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, People’s Republic of China;(3) Department of Molecular Biology and Microbiology School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;(4) Dept. of Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, Ohio 44195, USA;(5) Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, USA;(6) Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA;
Abstract:

Purpose  

To study the effectiveness of a peptide targeted nanoglobular Gd-DOTA complexes for MR molecular imaging of prostate cancer in a mouse orthotopic PC-3 prostate cancer model.
Keywords:
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