| 环带拟盘多毛孢发酵液中一个新的联苯类化合物(英文) |
| |
| 引用本文： | 杨小龙,张苏,宋少俊,张岩,罗都强,张萌.环带拟盘多毛孢发酵液中一个新的联苯类化合物(英文)[J].中国天然药物,2011(2):101-104. |
| |
| 作者姓名： | 杨小龙 张苏 宋少俊 张岩 罗都强 张萌 |
| |
| 作者单位： | 河北大学药物化学与分子诊断省部共建教育部重点实验室;河北大学药学院;河北大学生命科学学院; |
| |
| 基金项目： | supported by the programs for New Century Excellent Talents in University (No. NCET-09-0112); Hundred Excellent Innovation Talents from the Universities and Colleges of Hebei Province (No. SPRC008); the Key Project of Chinese Ministry of Education and the Key Applied Basic Research Programs of Hebei Province (No. 0996030917D); the National Natural Science Foundation of China (31071701)~~ |
| |
| 摘 要： | 目的:研究分离于海南红槟榔中环带拟盘多毛孢发酵液的化学成分。方法:利用硅胶柱层析和凝胶柱层析分离纯化得到4个化合物(1~4),借助光谱学手段鉴定其结构。测试了化合物1对大肠埃希氏菌、金黄色葡萄球菌、铜绿假单胞菌、肺炎克来伯氏菌、MRSA耐甲氧西林金黄色葡萄球菌、鲍曼不动杆菌和VRE耐万古霉素屎肠球菌的抑制活性。结果:分离鉴定了4个化合物包括1个新化合物(2'-乙酰基-4',4-二甲氧基联苯-2-醛基),该化合物对7种细菌株有较弱抑制活性,IC50分别为0.75,0.75,0.82,0.81,0.84,0.90和0.87μm·mL-1.结论:化合物1为新的联苯类化合物,对7种细菌株表现出比较弱的抑制活性。化合物2~4为首次从该种中分离得到。
|
| 关 键 词： | 环带拟盘多毛孢 红槟榔 抗细菌活性 植物内生真菌 |
A New Biphenyl from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka |
| |
| YANG Xiao-Long,ZHANG Su,SONG Shao-Jun,ZHANG Yan,LUO Du-Qiang,ZHANG Meng Key Laboratory of Pharmaceutical Chemistry , Molecular Diagnosis of Ministry of Education,Hebei University,Baoding ,China,College of Pharmaceutical Science,College of Life Science.A New Biphenyl from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka[J].Chinese JOurnal of Natural Medicines,2011(2):101-104. |
| |
| Authors: | YANG Xiao-Long ZHANG Su SONG Shao-Jun ZHANG Yan LUO Du-Qiang ZHANG Meng Key Laboratory of Pharmaceutical Chemistry Molecular Diagnosis of Ministry of Education Hebei University Baoding China College of Pharmaceutical Science College of Life Science |
| |
| Institution: | YANG Xiao-Long1,2,ZHANG Su2,SONG Shao-Jun2,ZHANG Yan2,LUO Du-Qiang1,3,ZHANG Meng2 1Key Laboratory of Pharmaceutical Chemistry and Molecular Diagnosis of Ministry of Education,Hebei University,Baoding 071002,China,2College of Pharmaceutical Science,3College of Life Science |
| |
| Abstract: | AIM: To investigate the chemical constituents of the fermentation broth of the plant endophytic fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka in Hainan, China. METHOD: Compounds 1-4 were separated and purified by silica gel chro-matography and Sephadex LH-20. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 was tested for its antibacterial activity against the bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, methi... |
| |
| Keywords: | Pestalotiopsis zonata Cyrtotachys lakka Antimicrobial activity Plant endophytic fungus |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
