毛鱼藤根中的一个新神经酰胺(英文)

目的:对毛鱼藤根化学成分进行分离和鉴定。方法:通过多种层析方法分离纯化化合物,用波谱解析方法进行结构鉴定。结果:从毛鱼藤根中分离到4个脂质化合物,包含3个神经酰胺:(2S,3S,4R,8E)-2N-(2′R,3′)-2′,3′-dihydroxy-hexacosanoyl]-1,3,4-trihydroxy-8-octadecene(1),(2S,3S,4R,8E)-2N-(2′R)-2′-hydroxyhexacosanoyl]-1,3,4-trihydroxy-8-octadecene(2),1-O-β-D-glucopyranosyl-(2S,3S,4R,8E)-2N-(2′R)-2′-hydroxytetracosanoyl]-3,4-dihydroxy-8-octadecene(3),和1个多羟基十八烷酸:12,13,15-trihydroxy-9-octadecenoicacid(4)。结论:化合物1为新化合物,也是首个C-3′有羟基取代的新神经酰胺。化合物2-4为鱼藤属植物中首次发现的化合物。

A Novel Ceramide from the Roots of Derris elliptica

AIM： To study the chemical constituents from the roots of Derris elliptica （Roxb.） Benth. METHODS： The chemical constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analysis. RESULT： Four lipid constituents were obtained, including three ceramides, （2S, 3S, 4R, 8E）-2N-（2′R, 3′）-2′, 3′-dihydroxyhexacosanoyl]-1, 3, 4-trihydroxy-8-octadecene （1）, （2S, 3S, 4R, 8E）-2N-（2′R）-2′-hydroxyhexacosanoyl]-1, 3, 4-trihydroxy-8-octadecene （2）, 1-O-β-D-glucopyranosyl-（2S, 3S, 4R, 8E）-2N-（2′R）-2′-hydroxytetracosanoyl]-3, 4-dihydroxy-8-octadecene （3）, and a polyhydroxyl octadecenoic acid, 12, 13, 15-trihydroxy-9-octadecenoic acid （4）. CONCLUSION： Compound 1 is a novel ceramide with hydroxyl group at C-3′, and is the first occurrence of ceramides with hydroxyl group at C-3′. Compounds 2-4 were isolated from genus Derris for the first time.