Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus |
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Authors: | Lusida M I Soetjipto Handajani R Nidom C A Soemarto Darmadi S Adi P Fujii M Fujita T Ishido S Hotta H |
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Affiliation: | Tropical Disease Center, Airlangga University, Surabaya, Indonesia. |
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Abstract: | The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this result being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains. |
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