IGF-1R和IRS-1在肺鳞癌组织中的表达及临床意义

目的 检测胰岛素样生长因子1受体(IGF-1R)和胰岛素受体底物1(IRS-1)在肺鳞癌组织中的表达,探究其在肺鳞癌发生发展中的作用及临床意义。方法 采用免疫组化法检测246例肺鳞癌组织与40例癌旁正常组织中IGF-1R、IRS-1的表达情况,并分析两者的相关性及与临床病理特征和预后的关系。结果 IGF-1R在肺鳞癌组织中的阳性表达率明显高于癌旁组织,其表达率分别为54.07%和32.5%,IRS-1在肺鳞癌组织中的阳性表达率明显低于癌旁组织,其表达率分别为38.21%和70%,各组间差异均有统计学意义(P＜0.05)。IGF-1R的表达与淋巴结转移相关(P＜0.05),IRS-1的表达与肺鳞癌组织的分化程度、淋巴结转移相关(P＜0.05)。IGF-1R阳性表达组患者的生存期明显短于IGF-1R阴性表达组患者,IRS-1阳性表达组患者的生存期明显长于IRS-1阴性表达组患者,差异有统计学意义(P＜0.001,P＜0.05)。IGF-1R与IRS-1在肺鳞癌组织中的表达呈负相关(r=-0.125,P＜0.001)。结论 IGF-1R、IRS-1都参与了肺鳞癌的发生、发展,且IGF-1R为独立预后因子。

Expressions and clinical significances of IGF-1R and IRS-1 in squamous cell lung cancer

Objective The aim of the study is to detect the expression of IGF-1R and IRS-1 in squamous cell lung cancer(SQCLC)and to explore the role in the development of squamous cell lung cancer and clinical significance.Methods Specimens from 246 surgical SQCLC and 40 adjacent normal lung tissues were evaluated for IGF-1R and IRS-1 expression by immunohistochemistry.We explored the correlation between IGF-1R and IRS-1,their relationship with clinicopathological parameters and their impact on outcome in SQCLC patients.Results SQCLC of IGF-1R positive expression rate was 54.07%,which was higher than in adjacent normal tissue(32.5%),SQCLC of IRS-1 positive expression rate was 38.21%,which was lower than in adjacent normal tissue(70%),the pairwise difference was statistically significant(P＜0.05);Expression of IGF-1R was correlated with lymph node metastasis(P＜0.05),IRS-1 expression was related with degree of differentiation and lymph node metastasis(P＜0.05).Survival of IGF-1R expression group of patients was significantly shorter than the expression of IGF-1R negative patients,the survival of the IRS-1 expression was significantly longer than patients who negatively expressed IRS-1,the difference was statistically significant(P=＜0.001 and =0.021).IGF-1R was negatively correlated with IRS-1 expression in SQCLC(r=-0.125,P＜0.001).Conclusion IGF-1R,IRS-1 are involved in the occurrence of SQCLC,the development.The IGF-1R is an independent prognostic factor in SQCLC.