LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效

目的 观察并探讨宫颈环形电切术(LEEP)联合干扰素及重组人IL-2对宫颈上皮内瘤变Ⅱ(CIN Ⅱ)伴高危型HPV疗效的影响。方法 选取2012年2月-2013年2月160例行LEEP术的CIN Ⅱ患者并随机分为四组(每组40例):对照组仅采用LEEP术治疗;A组采用LEEP术联合干扰素治疗;B组采用LEEP术联合重组人IL-2治疗;C组采用LEEP术联合干扰素及重组人IL-2治疗。治疗3个月、6个月后复查TCT、阴道镜及HPV,并对患者的疗效、并发症、HPV-DNA转阴率情况进行比较。结果 6个月后C组治愈率及HPV-DNA转阴率分别为92.5%、95%,高于其他三组(P＜0.05);与其他三组相比,C组创面愈合时间、阴道出血时间与阴道排液持续时间更短(P＜0.05)。结论 LEEP联合干扰素及白介素对CIN Ⅱ级伴高危型HPV的治疗效果明显优于单纯采用LEEP术及LEEP术单用干扰素或白介素,且愈合时间短,并发症较少,值得在临床上推广应用。

Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV

Objective To observe the therapeutic effect of cervical intraepithelial neoplasia Ⅱ(CIN Ⅱ)associated high risk HPV with LEEP combined interferon and recombinant human interleukin-2.Methods One hundred and sixty patients with CIN Ⅱ were selected during Feb.2012 and Feb.2013.The patients were randomly divided into four groups(40 patients in each group):the control group(LEEP),group A(LEEP united with interferon),group B(LEEP united with recombinant human interleukin-2)and group C(LEEP united with interferon and recombinant human interleukin-2).TCT,colposcope examination and HPV were reviewed,and the curative effects,postoperative complications and negative conversion rate of HPV-DNA were compared after three and six months of the treatment.Results The cure rate and negative conversion rate of HPV-DNA in group C were 92.5% and 95%,which were significantly higher than others groups(P＜0.05)after six months of treatment.The time of wound healing,duration of vaginal discharge and bleeding time in group C were also shorter than others groups(P＜0.05).Conclusion The therapeutic effect of LEEP combined with interferon and recombinant human interleukin-2 is superior to LEEP and LEEP united interferon or interleukin-2,which is not only shorter healing time,but also fewer complications.The therapeutic method is worthy to be applied widely.