| 抑制性协同刺激分子B7-H4在女性常见恶性肿瘤中的研究进展 |
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| 引用本文： | 万静华,傅振坤.抑制性协同刺激分子B7-H4在女性常见恶性肿瘤中的研究进展[J].实用肿瘤学杂志,2015,29(1):53-56. |
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| 作者姓名： | 万静华 傅振坤 |
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| 作者单位： | 1.中国人民解放军61565部队门诊部(北京 102600);2.哈尔滨医科大学免疫学教研室 |
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| 基金项目： | 中国博士后科学基金第52批面上资助(2012M520036) |
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| 摘 要： | B7-H4,又称V-set域T细胞激活抑制因子-1(VTCN-1),是免疫协同刺激分子B7分子超家族的新成员,其对于T淋巴细胞介导的免疫应答起到负向调节的作用,B7-H4可抑制T细胞的增殖和细胞因子的产生。B7-H4的表达与肿瘤的发生、发展及转归有着重要的联系,近年来女性常见恶性肿瘤与B7-H4的关系也受到关注。本文将对B7-H4分子与女性常见恶性肿瘤的关系进行综述,并阐述B7-H4分子作为女性恶性肿瘤潜在诊断和治疗新靶点的进展。
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| 收稿时间： | 2014-08-21 |
Reviews on association between the inhibitory costimulatory molecules B7 -H4 and female malignant tumor |
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| WAN Jinghua,FU Zhenkun.Reviews on association between the inhibitory costimulatory molecules B7 -H4 and female malignant tumor[J].Journal of Practical Oncology,2015,29(1):53-56. |
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| Authors: | WAN Jinghua FU Zhenkun |
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| Institution: | 1.Out-Patient Department,Unit 61565 of PLA,Beijing 102600,China;2.Department of Immunology,Harbin Medical University |
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| Abstract: | The new costimulatory molecule B7-H4,also called V-set domain containing T cell activation inhibitor 1(VTCN-1),is a member of the B7 family.B7-H4 can negatively regulate the immune response of T lymphocytes through inhibiting their proliferation and cytokine production.The expression of B7-H4 plays an important role in initiation,progression and regression of malignant tumors,including female malignant tumor,such as breast cancer,ovarian cancer and uterine neoplasm.The association between the female tumors and B7-H4 causes great concern in recent years.In this review,the function of B7-H4 in female tumor research and the potential target of B7-H4 in the diagnosis and treatment of female tumor are summarized. |
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