非增生型糖尿病视网膜病变患者眼部血流动力学指标与中心视网膜厚度的关系

目的 探讨非增生型糖尿病视网膜病变(NPDR)患者眼部血流动力学指标与中心视网膜厚度的关系。方法 选取2019年8月至2021年10月在我院糖尿病视网膜病科就诊并确诊为NPDR的患者208例(208眼)。根据黄斑及周围视网膜正常厚度参考值将所有患者分为中心视网膜厚度正常组(216.4～<304.5μm)88例(88眼)、中心视网膜变薄组(<216.4μm)56例(56眼)和中心视网膜增厚组(≥304.5μm)64例(64眼)。所有患者均行常规眼科检查，采用OCT测量患者中心视网膜厚度，眼部彩色多普勒超声诊断仪测得患者完整的眼部血流动力学指标。检测患者眼动脉(OA)、视网膜中央动脉(CRA)及睫状后短动脉(PCA)的收缩期血流峰值速度(PSV)、搏动指数(PI)和阻力指数(RI),分析NPDR患者血流动力学指标与中心视网膜厚度的相关性。结果 三组患者OA、CRA、PCA血流动力学指标PSV、PI、RI比较，差异均有统计学意义(均为P<0.05);中心视网膜增厚组患者OA、CRA、PCA的PSV均小于中心视网膜厚度正常组，PI和RI均大于中心视网膜厚度正常组，差异均有统计...

Ocular hemodynamic parameters of patients with non-proliferative diabetic retinopathy and their correlation with central retinal thickness

Objective　To investigate the ocular hemodynamic parameters and their relationship with the central retinal thickness in patients with non-proliferative diabetic retinopathy (NPDR). Methods　A total of 208 patients (208 eyes) with NPDR who were admitted to our Department of Diabetic Retinopathy and diagnosed with NPDR from August 2019 to October 2021 were included. Totally 88 patients (88 eyes) were divided into the normal central retinal thickness group (216.4-<304.5 μm), 56 patients (56 eyes) were included in the central retinal thinning group (<216.4 μm), and 64 patients (64 eyes) were included in the central retinal thickening group (≥304.5 μm) according to the reference values of the macular and surrounding retinal thickness. All patients underwent routine ophthalmologic examinations. Optical coherence tomography (OCT) was used to measure the central retinal thickness, and the color Doppler ultrasound instrument was used to measure the complete ocular hemodynamic parameters. The peak systolic velocity (PSV), pulsatility index (PI) and resistance index (RI) of the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary artery (PCA) were measured, and the correlation between hemodynamic parameters and central retinal thickness was analyzed. Results　There were statistically significant differences in the PSV, PI and RI of OA, CRA and PCA among the three groups (all P<0.05). The PSV for OA, CRA and PCA of patients in the central retinal thickening group were smaller than those in the normal central retinal thickness group, while PI and RI were greater than those in the normal central retinal thickness group; the differences were statistically significant (all P<0.05). The PSV, PI and RI of OA and CRA in the central retinal thinning group were smaller than those in the normal central retinal group (all P<0.05); the PSV of PCA was greater than that in the normal central retinal group, while PI and RI were smaller than those in the normal central retinal group (all P<0.05). The PSV of OA, CRA and PCA of patients in the central retinal thickening group were smaller than those in the central retinal thinning group, and the PI and RI were greater than those in the central retinal thinning group; the differences were statistically significant (all P<0.05). The PSV of OA, CRA, and PCA were not correlated with the central retinal thickness in NPDR patients (all P>0.05), while the PI and RI were positively correlated with the central retinal thickness (all P<0.05). Conclusion　There is a close relationship between central retinal thickness and ocular hemodynamic parameters in NPDR patients.