膳食含糖饮料摄入与高尿酸血症风险相关性的meta分析

目的采用meta分析方法系统评价含糖饮料(sugar-sweetened beverages,SSBs)摄入与高尿酸血症(hyperuricemia,HUA)发生风险之间的关系。方法系统检索PubMed、中国知网(CNKI)、万方数据库(Wanfangdata)以及维普数据库(VIP)中截至2021年12月31日公开发表的有关SSBs摄入量与HUA发生风险的观察性研究,严格遵守纳入和排除标准筛选文献并提取有效数据,应用Stata v.16.0软件进行异质性检验、亚组分析、回归分析、敏感性分析、发表偏倚检测和剂量-反应分析。结果共纳入参考文献10篇,其中包括1篇病例对照研究和9篇横断面研究,共纳入研究对象66559例,包括HUA患者12108例。分析结果显示,膳食SSBs摄入是HUA发病的风险因素(OR=1.37,95%CI:1.25~1.49),剂量-反应分析结果显示,SSBs摄入量与HUA发病风险之间呈现非线性正相关。结论膳食SSBs摄入与HUA之间存在相关性,高SSBs摄入可以增加HUA发病风险。

Correlation between intake of dietary sugar-sweetened beverages and risk of hyperuricemia: a meta-analysis

Objective To systematically evaluate the association betweenintake of dietary sugar-sweetened beverages (SSBs) and risk of hyperuricemia (HUA) based on a meta-analysis. Methods Databases of PubMed, CNKI, Wanfang Data, and VIP were systematically retrieved for choosing published observational studies on SSBs intake and risk of HUA as of December 31, 2021. The articles were screened strictly according to inclusion and exclusion criteria, and valid data were extracted. Stata v.16.0 was used to perform heterogeneity test, subgroup analysis, meta-regression analysis, sensitivity analysis, publication bias assessment and dose-response analysis. Results A total of 10 articles, including 1 case-control study and 9 cross-sectional studies, were enrolled in this study. 66,559 participants were involved, including 12,108 cases of HUA. The analysis results showed that dietary SSBs intake was a risk factor for occurrence of HUA (OR=1.37, 95%CI:1.25-1.49), and the results of dose-response analysisrevealed that there was a non-linear positive correlation between SSBs intake and risk of HUA. Conclusion There is a correlation between dietary SSBs intake and HUA, and high SSBs intake can increaserisk of HUA onset.