碘[131I]化钠口服溶液治疗分化型甲状腺癌场所空气中131I浓度检测

目的 研究核医学科碘¹³¹I]化钠口服溶液治疗分化型甲状腺癌（DTC）患者时，治疗场所空气中¹³¹I放射性浓度，评估工作人员内照射剂量。方法 选取某医院核医学科DTC患者¹³¹I住院治疗的工作场所。分别对¹³¹I服药区和¹³¹I治疗病房空气进行气体采样，通过低本底伽玛谱仪探测样本，经计算空气中¹³¹I的活度浓度，估算工作人员受到的内照射剂量。结果 在¹³¹I服药区，服药3 h内活度浓度为3～187 Bq/m³。患者服药期间及患者服药后3 h、在服药处停留5～30 min，内照射剂量分别为0.08～0.50 μSv及0.00～0.04 μSv。患者服药当天病房空气中¹³¹I的活度浓度最高，可达3 091 Bq/m³；患者出院后，病房活度浓度逐渐降低，在48 h内浓度为10～242 Bq/m³。出院后48 h内 在病房停留5～30 min，内照射剂量为0.01～14.11 μSv 。结论 ¹³¹I治疗DTC患者服药期间空气中¹³¹I活度浓度较高，建议采用远程给药或观察窗给药。患者住院期间，病房内¹³¹I活度浓度最高，建议除医护人员外，禁止其他人员进入病房。患者出院后，尽量延后进入病房的时间，以减少内照射剂量。

Radioactive concentration of 131I in the air of treatment workplaces for differentiated thyroid cancer with sodium iodide [131I] oral solution

Objective To study the radioactive concentration of ¹³¹I in the air of workplaces where sodium iodide ¹³¹I] oral solution was administrated for patients with differentiated thyroid cancer (DTC) in the Department of Nuclear Medicine, and to estimate the internal radiation dose to the staff. Methods Workplaces of radioiodine ¹³¹I therapy for DTC patients in the Department of Nuclear Medicine of a hospital were investigated. Air samples in ¹³¹I administration areas and treatment wards were collected respectively and were measured by low-background gamma-ray spectrometry to calculate the activity concentration of ¹³¹I in the air and to further estimate the internal radiation dose to staffs. Results The activity concentration in the ¹³¹I administration area within the first 3 h of administration was 3～187 Bq/m³. During administration and within the first 3 h of administration, the staff exposed in the administration area for 5～30 min received an internal radiation dose of 0.08～0.50 μSv and 0.00～0.04 μSv, respectively. The highest activity concentration of ¹³¹I in the air of the ward was measured on the day of administration, reaching 3091 Bq/m³. After patients were discharged, the activity concentration in the ward gradually decreased to 10～242 Bq/m³ within 48 h. Within 48 h after patients were discharged, the staff exposed in the ward for 5～30 min received an internal radiation dose of 0.01～14.11 μSv. Conclusion A high activity concentration of ¹³¹I in the air was recorded during administration for DTC patients in radioiodine ¹³¹I therapy, and thus we recommend remote instructed administration or administration through a shielded window. We also recommend that non-treatment related personnel except medical staffs should not enter the ward during patients’ hospitalization at which the activity concentration of ¹³¹I in the ward was the highest. After patients were discharged, a delayed entry into the ward is recommended to reduce the internal radiation dose.