硅水凝胶角膜接触镜senofilcon A和comfilcon A在LASEK术后应用的对比研究

目的 对比硅水凝胶角膜接触镜senofilcon A和comfilcon A在准分子激光上皮下角膜磨镶术(LASEK)术后应用的临床效果.方法 采用前瞻性随机双盲自身对照试验的方法,纳入行LASEK患者39例(78眼),术后同一患者一眼配戴senofilcon A角膜接触镜(A组),另一眼配戴comfilcon A角膜...

Comparison of clinical effects of senofilcon A and comfilcon A silicone hydrogel contact lenses after laser-assisted subepithelial keratectomy

Objective　To evaluate and compare the clinical effect of senofilcon A and comfilcon A silicone hydrogel contact lenses following the laser-assisted subepithelial keratectomy (LASEK).Methods　A prospective, randomized, double-blind, self-control trial was conducted in 39 patients (78 eyes) who underwent LASEK. After the operation, one eye wore senofilcon A lens (group A) and the fellow eye wore comfilcon A lens (group B) for 7 consecutive days. The subjective feelings and objective signs between the two groups were evaluated and compared.Results　On the day of surgery, the pain score of eyes in group B was 2.03±2.03, higher than that in group A (1.49±1.68) (P=0.024). On the first day after surgery, the scores for eye pain, lacrimation and foreign body sensation in group B were higher than those in group A (P_eye pain=0.001, P_lacrimation=0.032, P_foreign body sensation=0.025). On the third and seventh days after surgery, there was no significant difference in subjective feelings between the two groups (all P>0.05). During the observation period, there was no significant difference between the two groups in objective signs, such as visual acuity, corneal epithelial healing, corneal epithelial edema, and conjunctival congestion (all P>0.05).Conclusion　Senofilcon A and comfilcon A silicone hydrogel contact lenses have no significant difference in promoting corneal epithelial regeneration after LASEK. However, senofilcon A lenses are more comfortable than comfilcon A lenses in the early postoperative period.