针刺疗法辅助治疗格林-巴利综合征的临床研究

目的 观察针刺疗法辅助治疗格林巴利综合征(GBS)的临床疗效。方法 以三亚市中医院2019年2月—2021年10月收治的169例GBS患者为研究对象，随机数字表法分为对照组(83例)和观察组(86例),其中西药对照组50例，西药观察组50例，中药对照组33例，中药观察组36例。对照组给予常规西药或中药治疗，观察组在对照组治疗基础上另给予针刺辅助治疗，疗程4周。比较治疗前后对照组和观察组四肢肌力、神经功能[运动神经传导速度(MCV)、感觉神经传导速度(SCV)]、中医证候积分、临床疗效、血清炎性因子[白介素-10(IL-10)、白介素-18(IL-18)]水平及安全性指标变化情况。结果 治疗后，西药、中药观察组四肢肌力明显升高(P<0.05,P<0.01),优于对照组(P<0.05);西药、中药观察组正中神经、胫神经MCV、SCV明显升高(P<0.05),优于对照组(P<0.05);西药、中药观察组中医证候评分明显低于治疗前，并低于对照组(P<0.05);西药、中药观察组治疗总体有效率明显高于对照组(P<0.05);西药、中药观察组IL-10水平...

Clinical Study of Acupuncture Therapy as An Auxiliary Treatment for Guillain-Barre Syndrome

  OBJECTIVE  To observe the clinical efficacy of acupuncture therapy in the auxiliary treatment of Guillain-Barre syndrome (GBS).  METHODS  A total of 169 patients with GBS admitted to Sanya TCM Hospital from February 2019 to October 2021 were studied, and were divided into control group (83 cases) and observation group (86 cases) by random number table method. There were 50 cases in the western medicine control group, 50 cases in the western medicine observation group, 33 cases in the Chinese medicine control group, and 36 cases in the Chinese medicine observation group. The control group was treated with conventional western or Chinese medicine therapies, while the observation group was given acupuncture-auxiliary treatment based on the therapies in the control group. The treatment course lasted four weeks. In addition, we compared the muscle strength of the limbs, nerve function [motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV)], traditional Chinese medicine (TCM) syndrome scores, clinical efficacy, serum inflammatory factors [interleukin-10 (IL-10), interleukin-18 (IL-18)] levels, as well as safety indexes in the control group and the observation group before and after treatment.  RESULTS  After treatment, the muscle strength of the of limbs was significantly increased in the western and Chinese medicine observation groups (P < 0.05, P < 0.01), whose results were better than those in the control group (P < 0.05). Besides, the MCV and SCV of the median nerve and tibial nerve were significantly increased in the western and Chinese medicine observation groups (P < 0.05), whose results were also better than those in the control group (P < 0.05). In addition, TCM syndrome scores were significantly reduced in the western and Chinese medicine observation groups compared to pre-treatment results and lower than those in the control group (P < 0.05). The total effective rates of treatment in the western and Chinese medicine observation groups were significantly increased than those in the control group (P < 0.05). on top of that, the IL-10 levels in the western and Chinese medicine observation groups were significantly increased (P < 0.01) and higher than those in the control group (P < 0.05), while IL-18 levels were significantly reduced (P < 0.01) and lower than those in the control group (P < 0.05). There were no notable complications in all groups.  CONCLUSION  Acupuncture auxiliary therapy can significantly optimize the clinical efficacy of western and Chinese medicine treatment. Besides, it can improve patients' muscle strength and neurological function, mitigate clinical syndromes, and restore patients' serum inflammatory factor levels.