饮水习惯与上尿路尿路上皮癌病理特征的相关性分析

目的：探究饮水习惯与上尿路尿路上皮癌(upper tract urothelial carcinoma, UTUC)患者的临床病理特征之间的相关性。方法：选取北京大学第一医院泌尿外科2020年8月至2021年7月收治的拟行根治性切除术的UTUC患者，在术前进行问卷调查，了解其饮水习惯，结合其术后病理特点进行统计分析。统计过程采用SPSS 22.0软件，首先采用列联表χ²检验，对UTUC肿瘤病理特点作为因变量与患者一般信息、既往史及饮水习惯相关因素等作为自变量逐一进行初步分析，筛选出针对各因变量病例组和对照组之间满足P<0.2的自变量，将筛选后的变量纳入二元Logistic回归分析，以P<0.05为差异有统计学意义。结果：共纳入239例患者，男性134例，女性105例，平均年龄(68.1±9.98)岁，中位病程4.8个月。统计结果提示，经调整了混杂因素的影响后，有白天每小时至少饮水1次习惯的UTUC患者患高级别(G3)肿瘤的概率增加(OR=1.941, 95%CI:0.352～1.029,P<0.01);有白天每小时至少饮水1次习惯的患者相对于没有...

Correlation between daily fluid intake behavioral habits and pathological characteristics of upper tract urothelial carcinoma

Objective: To investigate the correlation between drinking habits and pathological characteristics of patients with upper tract urothelial carcinoma (UTUC). Methods: A preoperative questionnaire survey was conducted to understand the drinking habits of UTUC patients who were admitted to the Department of Urology, Peking University First Hospital for radical nephroureterectomy within one year from August 2020 to July 2021, and statistical analysis was performed in combination with their postoperative pathological characteristics. The statistical procedure was performed using SPSS 22.0 software, and firstly, the preliminary analysis was performed one by one using the columnar χ² test on the pathological characteristics of UTUC tumors as the dependent variable and the factors related to patients' general information, past history and drinking habits as the independent variables, and the independent variables that met P < 0.2 between the case and control groups for each dependent variable were specified for screening. The screened variables were included in the binary Logistic regression analysis. A difference of P < 0.05 was used to indicate a statistically significant difference. Results: A total of 239 patients, 134 males and 105 females, with a mean age of (68.1±9.98)years and a median disease duration of 4.8 months, were included in this study. Multifactorial Logistic regression results suggested that after adjusting for the effects of other variables, UTUC patients who had the habit of drinking at least once every hour during the daytime had a significantly increased risk of high grade (G3) tumors(OR=1.941, 95%CI: 0.352-1.029, P < 0.01); these patients also had a significantly decreased risk of multifocal UTUC tumors (OR=0.344, 95% CI: 1.18-5.582, P=0.004). The patients who had the habit of drinking over 100 mL water each time had a significantly decreased risk of mutifocal UTUC incidence (OR=0.477, 95%CI: 0.225-1.012, P=0.046). Patients who pay attention to daily water intakes had a significantly increased risk of renipelvic carcinoma (OR=2.530, 95%CI: 1.434-4.463, P=0.001) and a significantly decreased risk of ureteral carcinoma (OR=0.314, 95%CI: 0.172-0.573, P < 0.01). Other variables included in the regression model did not differ significantly in their effects on the occurrence of tumor pathological characteristics. Conclusion: Having the awareness of drinking water every 1 h during the day, drinking over 100 mL water each time, having the awareness of daily drinking habits correlated significantly with pathological characteristics of UTUC such as the presence of G3 tumor, multifocal tumors and location of the tumor. This conclusion still needs to be verified by subsequent trials with higher levels of evidence.