逍遥散合半夏厚朴汤对肝郁脾虚型抑郁症患者认知功能和事件相关电位P300的影响

目的 观察逍遥散合半夏厚朴汤对肝郁脾虚型抑郁症患者认知功能和事件相关电位P300的影响情况.方法 选取2019年4月-2021年10月浙江中医药大学附属温州市中医院收治的60例肝郁脾虚型抑郁症患者为研究对象,按随机数字表法分为研究组和对照组,每组30例.对照组患者予以艾司西酞普兰片口服治疗,研究组患者予以逍遥散合半夏厚...

Effect of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression

  Objective  To observe the effects of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression.  Methods  Sixty patients with liver depression and spleen deficiency depression in Wenzhou Hospital of Traditional Chinese Medicine from April 2019 to October 2021 were randomly divided into study group and control group, with 30 patients in each group. The patients in the control group were treated with escitalopram tablets orally, whereas those in the study group were treated with Xiaoyao Powder and Banxia Houpu Decoction. Before and 8 weeks after treatment, the changes of depression and cognitive function were evaluated. The changes of event-related potential P300 and adverse drug reactions were observed.  Results  After 8 weeks of treatment, the Hamilton Depression Scale(HAMD) score of the study group (12.67±1.62) points] was significantly lower than that of the control group (15.37±1.42) points, t=6.838, P < 0.001]. The performances IQ (PIQ), verbal IQ (VIQ) and full intelligence quotient (FIQ) scores (100.13±3.47) points, (104.57±3.04) points and (102.53±2.37) points, respectively] in the study group were significantly higher than those in the control group (96.97±3.20) points, (102.37±2.85) points and (99.87±2.21) points, respectively, all P < 0.05]. The MQ scores (77.77±3.32) points] in the study group were significantly higher than those in the control group (73.27±3.04) points, t=5.468, P < 0.001]. The WCST score indexes of patients in the study group were significantly lower than those in the control group (all P < 0.05). The latency of event-related potential P300 in the study group was significantly lower than that in the control group, and the amplitude of event-related potential P300 was significantly higher than that in the control group (all P < 0.05). The incidence of adverse reactions in the study group (3.33%) was significantly lower than that in the control group (26.67%, χ2=4.706, P=0.030).  Conclusion  Xiaoyao Powder and Banxia Houpu Decoction can effectively reduce the severity of depressive symptoms in patients with liver depression and spleen deficiency depression, improve the recovery level of cognitive function and improve the neuroelectrophysiological status. They have high safety.