阿尔茨海默病患者血清中Apelin13和FKBP5的表达水平及临床意义

目的 探究阿尔茨海默病（AD）患者血清中Apelin13和FK506结合蛋白51(FKBP5)的表达水平及意义。方法 选取93例AD患者（AD组），同时选取同年龄层体检的90例健康者（对照组）。比较2组血清Apelin13、FKBP5mRNA水平差异。Pearson相关分析Apelin13、FKBP5 mRNA与简易精神状态量表（MMSE）评分的相关性。采用受试者工作特征（ROC）曲线评估Apelin13、FKBP5 mRNA对AD患者重度认知功能障碍的诊断价值。结果 AD组患者MMSE评分、血清Apelin13水平较对照组降低，而FKBP5 mRNA水平较对照组升高（均P<0.01）。轻、中及重度组AD患者血清中Apelin13水平依次降低，而FKBP5 mRNA水平依次升高（均P<0.05）。二元Logistic回归分析显示，较高的MMSE评分、Apelin13是AD发生的保护因素，而较高的FKBP5 mRNA是AD发生的危险因素（均P<0.05）。AD患者MMSE评分与血清FKBP5 mRNA水平呈负相关，而与Apelin13水平呈正相关（均P<0.05）...

The serum expression level and clinical significance of Apelin13 and FKBP5 in patients with Alzheimer's disease

Objective To investigate the serum expression level and clinical significance of Apelin13 and FK506 binding protein 51 (FKBP5) in patients with Alzheimer's disease (AD). Methods A total of 93 AD patients were selected (the AD group), and 90 healthy subjects of the same age for physical examination were selected as the control group. The serum levels of Apelin13 and FKBP5 mRNA were compared between the groups. The correlation between Apelin13, FKBP5 mRNA and Mini-mental State Examination (MMSE) score was analyzed by Pearson correlation analysis. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of Apelin13 and FKBP5 mRNA for severe cognitive impairment in AD patients. Results The serum level of Apelin13 and MMSE scores were significantly lower in the AD group than those in the control group, while the level of FKBP5 mRNA was significantly higher in the AD group than that in the control group (P<0.01). The serum levels of Apelin13 decreased sequentially in patients with mild, moderate and severe AD, while levels of FKBP5 mRNA increased sequentially (all P<0.05). Binary Logistic regression analysis showed that higher MMSE score and Apelin13 were protective factors for AD, while higher FKBP5 mRNA was a risk factor for the development of AD (all P<0.05). MMSE score was negatively correlated with the serum level of FKBP5 mRNA and positively correlated with the level of Apelin13 in AD patients (all P<0.05). ROC curve showed that the AUC value [0.884 (0.808-0.961)] of Apelin13 combined with FKBP5 mRNA was significantly higher than that of Apelin13 or FKBP5 mRNA [0.776 (0.673-0.879) or 0.801 (0.699-0.902)], and the sensitivity and specificity of combined diagnosis were 81.25 and 86.89, respectively (all P<0.05). Conclusion The serum level of Apelin13 is decreased in AD patients, while FKBP5 mRNA is increased. Apelin13 combined with FKBP5 mRNA has good diagnostic efficacy for severe cognitive impairment in AD patients.