| 前列腺特异性膜抗原PET/MRI在前列腺癌中的应用现状与前景 |
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| 引用本文： | 李慧,杨志.前列腺特异性膜抗原PET/MRI在前列腺癌中的应用现状与前景[J].协和医学杂志,2022,13(2):192-198. |
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| 作者姓名： | 李慧 杨志 |
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| 作者单位： | 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科 国家药监局放射性药物研究与评价重点实验室 恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142 |
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| 基金项目： | 北京大学肿瘤医院科学研究基金2020-17 |
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| 摘 要： | 前列腺癌(prostate cancer, PCa)是常见的老年男性恶性肿瘤，并是其主要致死原因之一。前列腺特异性膜抗原(prostate specific membrane antigen, PSMA)是一种PCa组织特异性高表达的跨膜蛋白，这使得PSMA成为PCa良好的特异性分子影像靶点。目前，PSMA PET/CT在PCa诊断、分期等方面的价值已被广泛认可。随着PET/MRI逐步进入临床，PSMA PET与MRI两种诊断PCa的重要影像学方法的有机结合成为可能。本文就PSMA PET/MRI在PCa中的应用现状与前景进行阐述，以期为临床诊疗提供借鉴。
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| 关 键 词： | 前列腺癌 前列腺特异性膜抗原 PET/MRI |
| 收稿时间： | 2021-06-25 |
Prostate Specific Membrane Antigen PET/MRI for the Management of Prostate Cancer: Current Status and Future Directions |
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| Institution: | Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing 100142, China |
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| Abstract: | Prostate cancer (PCa) is one of the most common malignancies and one major leading cause of mortality from cancers in old men. Due to its specific overexpression in PCa cells, the prostate specific membrane antigen (PSMA) has become an ideal molecular imaging target for PCa.Currently, the value of PSMA PET/CT in the diagnosis and staging of PCa has been widely accepted. With the clinical application of simultaneous PET/MRI, it enables the possibility of combination of PSMA PET and MRI for the management of PCa. Here we present this review on the current status and future direction of the application of PSMA PET/MRI in the management of PCa. |
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