| MTFR2在肝癌组织中表达及临床意义的生物信息学分析 |
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| 引用本文： | 付宗立1,巨宇叶1,胡进静2,达玲玲2,严孟超1,朱晓亮3,李 汛3. MTFR2在肝癌组织中表达及临床意义的生物信息学分析[J]. 现代肿瘤医学, 2022, 0(9): 1628-1633. DOI: 10.3969/j.issn.1672-4992.2022.09.020 |
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| 作者姓名： | 付宗立1 巨宇叶1 胡进静2 达玲玲2 严孟超1 朱晓亮3 李 汛3 |
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| 作者单位： | 1.兰州大学第一临床医学院，甘肃 兰州 730000;2.甘肃省生物治疗与再生医学重点实验室，甘肃 兰州 730000;3.兰州大学第一医院普外科，甘肃 兰州 730000 |
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| 基金项目： | 甘肃省科技重大专项(编号:1602FKDA001);甘肃省科技计划项目(编号:18JR2TA018) |
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| 摘 要： | 目的:研究MTFR2在肝癌组织中的表达及临床意义。方法:通过TCGA数据库下载肝癌病人相关的mRNA测序数据及临床相关数据，使用R及Perl语言，数据挖掘研究MTFR2表达水平与肝癌患者预后、临床指标的相关性，进一步行GSEA-KEGG富集通路分析。结果:MTFR2表达水平在肝癌组织中高于正常组织，并且与临床分期、病理分级、T分期正相关，而且富集激活细胞周期、血管内皮再生等促进肿瘤的信号通路，抑制PPAR负调控肿瘤信号通路。结论:MTFR2是肝癌患者预后独立的危险因素，并且在肝癌的发生发展中发挥重要功能。
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| 关 键 词： | MTFR2 肝癌 预后 TCGA GSEA |
Bioinformatics analysis on MTFR2 expression and its clinical significance in hepatocellular carcinoma |
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| FU Zongli1,JU Yuye1,HU Jinjing2,DA Lingling2,YAN Mengchao1,ZHU Xiaoliang3,LI Xun3. Bioinformatics analysis on MTFR2 expression and its clinical significance in hepatocellular carcinoma[J]. Journal of Modern Oncology, 2022, 0(9): 1628-1633. DOI: 10.3969/j.issn.1672-4992.2022.09.020 |
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| Authors: | FU Zongli1 JU Yuye1 HU Jinjing2 DA Lingling2 YAN Mengchao1 ZHU Xiaoliang3 LI Xun3 |
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| Affiliation: | 1.The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China;2.Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine,Gansu Lanzhou 730000,China;3.Department of General Surgery,the First Hospital of Lanzhou University,Gansu Lanzhou 730000,China. |
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| Abstract: | Objective:To study the expression and clinical significance of MTFR2 in hepatocellular carcinoma tissue.Methods:mRNA sequencing data and clinical data related to hepatocellular carcinoma were downloaded from TCGA,and R and Perl languages were used for further data mining to study the correlation between MTFR2 expression level and prognosis and clinical characters of hepatocellular carcinoma,and to further analyze the GSEA-KEGG enrichment pathway.Results:MTFR2 expression level in hepatocellular carcinoma tissues was higher than that in normal tissues,and was positively correlated with clinical stage,pathological grade and T stage.Moreover,it could enrich and activate cell cycle,vascular endothelial regeneration and other signal pathways promoting tumor,and inhibit PPAR negative regulation of tumor signal pathways.Conclusion:MTFR2 is an independent prognostic risk factor for hepatocellular carcinoma and plays an important role in the occurrence and development of hepatocellular carcinoma. |
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| Keywords: | MTFR2 hepatocellular carcinoma prognosis TCGA GSEA |
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