| 肿瘤浸润性淋巴细胞在乳腺癌预后评估及免疫治疗中的应用进展 |
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| 引用本文： | 洪晨忱,姚峰. 肿瘤浸润性淋巴细胞在乳腺癌预后评估及免疫治疗中的应用进展[J]. 肿瘤防治研究, 2022, 49(11): 1180-1183. DOI: 10.3971/j.issn.1000-8578.2022.22.0332 |
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| 作者姓名： | 洪晨忱 姚峰 |
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| 作者单位： | 430060 武汉，武汉大学人民医院乳腺甲状腺外科 |
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| 摘 要： | 2020年女性乳腺癌已超越肺癌成为全球最常见的癌症，大量研究证实肿瘤浸润性淋巴细胞（TILs）对肿瘤具有杀伤力，并在识别肿瘤抗原中发挥重要作用，因此TILs在临床免疫治疗及乳腺癌预后评估中的应用受到广泛关注。本文综述了近期TILs在不同分子分型乳腺癌中的基础研究进展和临床应用现状，评估了TILs对乳腺癌预后评估及临床免疫治疗的价值。
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| 关 键 词： | 乳腺癌 肿瘤浸润性淋巴细胞 预后 免疫治疗 |
| 收稿时间： | 2022-04-02 |
Progress on Tumor Infiltrating Lymphocytes in Immunotherapy and Prognosis Evaluation of Breast Cancer |
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| HONG Chenchen,YAO Feng. Progress on Tumor Infiltrating Lymphocytes in Immunotherapy and Prognosis Evaluation of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2022, 49(11): 1180-1183. DOI: 10.3971/j.issn.1000-8578.2022.22.0332 |
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| Authors: | HONG Chenchen YAO Feng |
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| Affiliation: | Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer in 2020. A large number of studies have proved that tumor infiltrating lymphocytes (TILs) are lethal to tumors and play an important role in identifying tumor antigens. Therefore, the application of TILs in clinical immunotherapy and prognosis assessment of breast cancer has attracted wide attention. In this review, the basic research progress and clinical application of TILs in different molecular types of breast cancer are reviewed, and the value of TILs in judging breast cancer prognosis and predicting the therapeutic effect of clinical immunotherapy is evaluated. |
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| Keywords: | Breast cancer Tumor infiltrating lymphocytes Prognosis Immunotherapy |
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