卡泊三醇治疗斑秃疗效与安全性Meta分析

目的:系统评价卡泊三醇治疗斑秃的疗效与安全性。方法:使用检索词“斑秃、卡泊三醇”等,检索中国生物医学文献数据库、中国期刊全文数据库、维普、万方、PubMed、Embase和Cochrane library,检索时间为各大数据库建库至2021年7月30日。由2名研究员独立阅读、筛选和评价后,采用RevMan 5.4和Stata 15.1软件进行数据分析和处理。结果:共检索出111篇文献,根据纳入和排除标准,最终纳入5篇随机对照试验。Meta分析结果显示:卡泊三醇组治疗斑秃的有效率是对照组的1.65倍(95%CI 1.02~2.66,P<0.05),可明显降低脱发严重程度(SALT)评分(MD=-1.20,95%CI-1.62~-0.78,P<0.05),但不良反应发生率是对照组的2.85倍(95%CI 1.07~7.63,P=0.04)。结论:卡泊三醇治疗斑秃疗效显著,但临床上使用时应考虑其不良反应。

Efficacy and safety of calcipotriol in the treatment of alopecia areata: meta-analysis

Objective: To assess the efficacy and safety of calcipotriol in the treatment of alopecia areata systematically. Methods: The studies of calcipotriol in the treatment of alopecia areata were searched in several databases from the establishment of the database to July 30, 2021, including CBM, CNKI, VIP, Wanfang, PubMed, Embase and Cochrane Library. After evaluation of the studies by 2 independent researchers, the data were analyzed through RevMan 5.4 and Stata 15.1 software. Results: A total of 111 articles were found and 5 randomized controlled trials were included in the meta anlaysis. The results showed that the effective rate and incidence of adverse events in the calcipotriol group were 1.65 times and 2.85 times higher than that in the control group respectively, the Severity of Alopecia Tool score significantly reduced in the calcipotriol group(P<0.05). Conclusion: The efficacy of calcipotriol for the treatment of alopecia areata is highly effective, but the adverse reactions need to be considered.