颈静脉鼓室副神经节瘤6例及相关文献复习

目的:探讨颈静脉鼓室副神经节瘤的临床病理特点、诊断及鉴别诊断等。方法:搜集6例颈静脉鼓室副神经节瘤的临床病理资料，光镜下观察HE切片并进行免疫组织化学染色。结果:6例患者均为女性，年龄14～53岁，平均年龄44.7岁。主要临床表现为耳鸣、耳痛、听力下降。大体为红色肿物，部分见包膜；镜下瘤细胞呈巢团状、条索状排列，胞质丰富，核深染。免疫组化:Syn阳性，其他S100、CgA等均有不同程度表达，CKp、CD34、CD31、SMA阴性，Ki-67增殖指数较低，约<10%。结论:颈静脉鼓室副神经节瘤为罕见的头颈部肿瘤，确诊主要依据病理学形态及免疫表型特征。

Case report and literature review on 6 cases with jugulare tympanicum paraganglioma

Objective:To investigate the clinical pathological features,diagnosis and differential diagnosis of jugulare tympanicum paraganglioma.Methods:The clinical and pathological data of 6 cases about jugulare tympanicum paraganglioma were collected.HE sections were observed under light microscope and immunohistochemical staining was performed.Results:All the 6 patients were female.The age of patients was 14~53 years old with a mean age of 44.7 years old.The main clinical manifestations were tinnitus,earache and hearing loss.In general，the gross was red mass,part of which was enveloped.Microscopically,the tumor cells were distributed in clusters and cords，with abundant cytoplasm and hyperchromatic nuclei.Immunohistochemical study showed that positive expression of Syn,S100,CgA and negative expression of CKp,CD34,CD31 and SMA,but S100 and CgA were expressed in different degrees.The Ki-67-labeling index was low,about<10%.Conclusion:Jugulare tympanicum paraganglioma is a rare head and neck tumor.The diagnosis is mainly based on pathological morphology and immunohistochemical characteristics.