| 风湿性疾病患者结核分枝杆菌潜伏感染激活机制的研究进展 |
| |
| 引用本文： | 吴文琪,钟剑球,何娟,邓国防,王庆文. 风湿性疾病患者结核分枝杆菌潜伏感染激活机制的研究进展[J]. 中国防痨杂志, 2022, 44(9): 954-959. DOI: 10.19982/j.issn.1000-6621.20220243 |
| |
| 作者姓名： | 吴文琪 钟剑球 何娟 邓国防 王庆文 |
| |
| 作者单位： | 1.北京大学深圳医院风湿免疫科/深圳市炎症与免疫重点实验室,深圳 518036;2.国家感染性疾病临床医学研究中心/深圳市第三人民医院肺病二科,深圳 518112 |
| |
| 基金项目： | 国家自然科学基金(81974253);国家自然科学基金(81901641);广东省自然科学基金面上项目(2019A1515011112);深圳市科技创新委员会重点基础研究项目(JCYJ20200109140203849);深圳市卫生健康委员会医防融合风湿性疾病项目(0102018-2019-YBXM-1499-01-0414) |
| |
| 摘 要： | 风湿性疾病是一组自身免疫与炎症性疾病，其主要特征是免疫系统的紊乱。同时，随着各种免疫抑制剂、生物制剂在风湿性疾病中的应用，机体的免疫状态大大改变，从而使结核分枝杆菌潜伏感染激活的风险增加。为更好地了解风湿性疾病患者结核分枝杆菌潜伏感染激活的机制，以期进一步降低结核病的发生率和患者病亡率，笔者从结核感染的免疫反应机制、风湿性疾病患者结核分枝杆菌潜伏感染激活的机制、增加结核分枝杆菌潜伏感染激活风险的治疗药物等方面进行综述，以供参考。
|
| 关 键 词： | 风湿性疾病 分枝杆菌,结核 感染 综述文献(主题) |
| 收稿时间： | 2022-06-27 |
The research progress of the reactivation of latent tuberculosis infection in patients with rheumatic diseases |
| |
| Wu Wenqi,Zhong Jianqiu,He Juan,Deng Guofang,Wang Qingwen. The research progress of the reactivation of latent tuberculosis infection in patients with rheumatic diseases[J]. The Journal of The Chinese Antituberculosis Association, 2022, 44(9): 954-959. DOI: 10.19982/j.issn.1000-6621.20220243 |
| |
| Authors: | Wu Wenqi Zhong Jianqiu He Juan Deng Guofang Wang Qingwen |
| |
| Affiliation: | 1.Department of Rheumatology and Immunology, Peking University Shenzhen Hospital/Shenzhen Key Laboratory of Immunity and Inflammatory Disease, Guangdong Province, Shenzhen 518036, China;2.The Second Department of Pulmonary Diseases, Shenzhen Third People’s Hospital/National Clinical Research Center for Infectious Diseases, Shenzhen 518112, China |
| |
| Abstract: | Rheumatic diseases are a group of autoimmune and inflammatory diseases characterized by disorders of the immune system, while with the application of various immunosuppressants and biological agents in rheumatic diseases, the immune state of the body has been greatly altered, increasing the risk of activation of latent tuberculosis infection. To better understand the activation mechanism of latent tuberculosis infection in patients with rheumatic diseases and reduce the incidence and mortality, the immune response mechanisms of tuberculosis infection, the activation mechanism of latent tuberculosis infection with rheumatic diseases, and the therapeutic drugs that increase the risk of activation are reviewed for reference. |
| |
| Keywords: | Rheumatic diseases Mycobacterium tuberculosis Infection Review literature as topic |
|
| 点击此处可从《中国防痨杂志》浏览原始摘要信息 |
|
点击此处可从《中国防痨杂志》下载全文 |
