孕期子宫动脉超声参数动态分析与子痫前期风险的相关性研究

  目的  动态分析孕期患者子宫动脉超声参数及其与子痫前期发生风险的相关性。  方法  纳入2020年1月—2021年10月湖州市妇幼保健院接受子宫动脉超声检查的60例子痫前期患者为子痫前期组，另纳入同期接受子宫动脉超声检查的60例未发生子痫前期的孕妇为对照组。动态分析2组患者孕期子宫动脉超声参数及其与孕期孕妇子痫前期的相关性。  结果  2组孕妇随孕期的延长RI值、PI值、S/D值均降低，且对照组RI值、PI值、S/D值均低于子痫前期组(均P＜0.05)；Pearson相关系数分析显示，孕11~16周及孕20~24周RI值、PI值、S/D值与孕妇子痫前期风险呈正相关(r=0.602、0.774、0.638；r=0.809、0.833、0.608，均P＜0.05)；多因素logistic回归分析显示，孕11~16周及孕20~24周高RI值、高PI值、高S/D是孕期孕妇子痫前期的危险因素(OR=2.463、1.239、1.599；OR=1.643、1.568、1.741，均P < 0.05)；ROC曲线分析显示，孕11~16周子宫动脉超声参数预测价值(AUC为0.965)高于孕20~24周子宫动脉超声参数(AUC为0.885，P＜0.05)。  结论  随着孕期的延长孕妇子宫动脉RI、PI、S/D指标逐渐降低，与孕妇子痫前期发生风险呈正相关，并可作为孕妇子痫前期发生风险的预测指标。 

The correlation between the dynamic analysis of uterine artery ultrasound parameters during pregnancy and the risk of preeclampsia

  Objective  To dynamically analyse the ultrasound parameters of uterine arteries and their correlation with the risk of preeclampsia in pregnant patients.  Methods  A total of 60 cases of preeclampsia patients who received uterine artery ultrasonography in Huzhou Maternity and Children ' s Health Hospital from January 2020 to October 2021 were included in the preeclampsia group, and 60 patients who received uterine artery ultrasonography during the same period without preeclampsia were included as the control group. The ultrasound parameters of the uterine artery during pregnancy and their correlation with preeclampsia during pregnancy were dynamically analysed.  Results  The RI value, PI value and S/D value of pregnant women in both groups decreased with the prolongation of pregnancy, and the RI value, PI value and S/D value of the control group were lower than those of the preeclampsia group (all P < 0.05). Pearson correlation coefficient analysis showed that the RI value, PI value and S/D value at 11-16 weeks of pregnancy and 20-24 weeks of pregnancy were positively correlated with the risk of preeclampsia (r=0.602, 0.774, 0.638; r=0.809, 0.833, 0.608, all P < 0.05). Multivariate logistic regression analysis showed that high RI value, high PI value and high S/D value at 11-16 weeks of pregnancy and 20-24 weeks of pregnancy were the risk factors of preeclampsia in pregnant women (OR=2.463, 1.239, 1.599; OR=1.643, 1.568, 1.741, all P < 0.05). ROC curve analysis showed that the predictive value of uterine artery ultrasound parameters at 11-16 weeks of gestation (AUC was 0.965) was higher than the uterine artery ultrasound parameters at 20-24 weeks of gestation (AUC was 0.885, P < 0.05).  Conclusion  The RI, PI and S/D index of the uterine artery in pregnant women decrease with the prolongation of pregnancy, which is positively correlated with the risk of preeclampsia in pregnant women, and can be used as a predictor of the risk of preeclampsia in pregnant women.