寻常型银屑病患者皮肤屏障功能相关指标检测分析

目的:探讨寻常型银屑病患者皮损区与非皮损区、患者与正常人皮肤屏障功能相关指标之间的差异。方法:1.收集寻常型银屑病患者35例，健康志愿者36例，使用皮肤屏障功能测试仪测定患者皮损区、非皮损区、健康志愿者的皮肤角质层含水量、PH值及经皮水分流失(TEWL)。2.收集30例寻常型银屑病患者与34例健康志愿者的血清，分别采用压板法、分光光度法测定NO、VitE水平。结果:寻常型银屑病患者皮损区PH值为(5.69±0.61)高于非皮损区PH值和健康对照组PH值；皮损区含水量为(17.90±6.75),低于非皮损区及健康对照组；皮损区TEWL为(18.58±11.55)g/m²h,高于非皮损区和健康对照组；然而非皮损区与健康对照组的PH值、角质层含水量及TEWL无统计学差异；寻常型银屑病患者血清维生素E含量(7.27±0.96)μg/mL低于健康对照组，银屑病组血清NO含量(5.29±1.91)μg/mL高于健康对照组。结论:寻常型银屑病患者皮损区，皮肤屏障功能指标异常，表现在皮肤表面PH值升高、角质层含水量下降、TEWL值升高、血清VitE下降、血清NO升高。

Analysis of skin barrier function index with psoriasis vulgaris patients

Objective: To study the differences of skin barrier and related indicators between lesion area and non-lesion aera of psoriasis vulgaris patients, patients and healthy controls. Methods: 1. The skin stratum corneum moisture content, PH and transepidermal water loss (TEWL) were measured by skin barrier function tester in  35 patients with psoriasis vulgaris and 36 health volunteers; 2. The levels of serum NO and serum VitE were measured by clamp method and spectrophotometry in serum of 30 patients and 34 healthy controls. Results: The PH and TEWL of psoriasis lesions were (5.69+0.61) and (18.58 + 11.55), which were higher than the normal skin of patients and controls. Lesion area's The water content was (17.90+6.75) in the lesions which was lower than the normal skin of patients and controls. There was no statistically significant difference of PH, TEWL and water content in normal skin between patients and healthy controls. Compared with healthy controls, the level of VitE in patients was lowe and that of NO was higher. Conclusions: The indicators of skin barrier function of psoriasis lesion are abnormal, which are higher PH value, TEWL value and serum NO, lower water content of stratum corneum and serum VitE.