醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿腹泻型肠易激综合征的疗效分析

  目的  探讨醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿腹泻型肠易激综合征(IBS)的疗效。  方法  选取2018年10月—2020年10月南阳市中心医院收治的104例腹泻型IBS患儿。采用随机数表法将患儿分为对照组和观察组，每组52例。对照组采用双歧杆菌四联活菌片治疗，观察组采用醒脾养儿颗粒联合双歧杆菌四联活菌片治疗。比较2组总有效率及不良反应发生情况，对比2组治疗前后中医证候积分、T淋巴细胞亚群以及脑肠肽指标。  结果  观察组总有效率为90.38%(47/52)，明显高于对照组的75.00%(39/52，χ2=4.299, P=0.038)。治疗后，观察组腹泻(1.26±0.32)分vs. (1.87±0.39)分]、腹痛(1.28±0.37)分vs. (1.94±0.43)分]、两胁胀满(0.74±0.16)分vs. (1.07±0.24)分]、恶心(0.54±0.13)分vs. (0.75±0.19)分]、纳少(0.47±0.18)分vs. (0.82±0.27)分]证候积分均明显低于对照组(均P＜0.05)。治疗后，观察组CD3+、CD4+、CD4+/CD8+水平高于对照组(均P＜0.05)；观察组CD8+水平低于对照组(t=4.418，P＜0.05)。治疗后，观察组P物质、神经降压素、胃动素和胃泌素水平高于对照组(均P＜0.05)。2组均未出现明显不良反应。  结论  醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿腹泻型IBS疗效确切，能明显改善患儿临床症状、调节T淋巴细胞亚群和脑肠肽指标水平。 

Efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhea predominant irritable bowel syndrome

  Objective  To investigate the efficacy of Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets in the treatment of infantile diarrhoea predominant irritable bowel syndrome (IBS).  Methods  A total of 104 children with diarrhoea-predominant IBS in Nanyang Central Hospital from October 2018 to October 2020 were selected and equally divided into control and observation groups by the random number table. The control group was treated with bifidobacterium quadruple viable tablets, and the observation group was treated with Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets. The total effective rate and adverse reactions were compared between the two groups. The traditional chinese medcine syndrome score, T lymphocyte subsets and brain gut peptide indexes of the two groups were compared before and after treatment.  Results  The total effective rate of the observation group was 90.38% (47/52), which was significantly higher than 75.00% (39/52) of the control group (χ2=4.299, P=0.038). After treatment, the syndrome scores of diarrhea (1.26±0.32) points vs. (1.87±0.39) points], abdominal pain (1.28±0.37) points vs. (1.94±0.43) points], fullness in both flanks (0.74±0.16) points vs. (1.07±0.24) points], nausea (0.54±0.13) points vs. (0.75±0.19) points], nausea (0.47±0.18) points vs. (0.82±0.27) points] in the observation group were significantly lower than those of the control group (all P < 0.05). After treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group (all P < 0.05); the level of CD8+ in the observation group was lower than that in the control group (t=4.418, P < 0.05). After treatment, the levels of substance P, neurotensin, motilin and gastrin in the observation group were higher than those in the control group (all P < 0.05). No obvious adverse reaction was found in the two groups.  Conclusion  Xingpi Yanger Granule combined with bifidobacterium quadruple viable tablets effectively treat infantile-diarrhoea-predominant IBS, can significantly alleviate clinical symptoms and regulates T lymphocyte subsets and brain gut peptide levels.