生物制剂背景下克罗恩病中西医结合治疗策略探讨

克罗恩病(Crohn' s disease, CD)作为慢性、进行性和致残性疾病, 严重影响患者生活质量。近年来随着生物制剂在国内的陆续上市, CD治疗已进入到了生物制剂时代, 治疗目标的不断升级，给临床诊疗带来了诸多挑战。中西医结合治疗可为CD患者提供优化的治疗手段，在生物制剂背景下如何发挥中西医结合治疗的特色和优势是值得关注的临床问题。笔者对生物制剂背景下CD中西医结合治疗策略进行阐述, 临床根据CD不同临床表现，中医可分别以“从痢”“从疡”“从痈”“从络”“从劳”的角度论治；从防治感染、抗纤维化、减少并发症、改善营养不良和促进透壁愈合等方面发挥中西医结合用药的特色优势, 以适应治疗目标的转变, 提高临床疗效。 

Exploration of Treatment Strategies with Integrated Traditional Chinese and Western Medicine for Crohn's Disease under the Background of Biological Agents

Crohn' s disease (CD) is a chronic, progressive and disabling disease, which seriously affects the quality of life of patients. In recent years, with the continuous listing of biological agents in China, the treatment of CD has entered the era of biological agents, which has brought about continuous upgrading of treatment goals and changes in treatment strategies. Integrated traditional Chinese and western medicine has provided optimized treatment methods for CD patients, so how to make use of the advantages of integrated traditional Chinese and western medicine in the background of biological agents is a importent clinical issue. This article elaborates the treatment strategy for CD under the background of biological agents. Clinically, according to the different clinical manifestations of CD, it can be treated from different perspectives of "Li", "Yang", "Yong", "Luo" and "Lao", from the prevention and treatment of infection, anti-fibrosis, reduction of complications, and improvement of malnutrition In order to adapt to the change of treatment goals and improve clinical efficacy.