| 脂阿拉伯甘露聚糖的结构功能及其在结核病诊断中的应用 |
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| 引用本文： | 唐明慧,李浩. 脂阿拉伯甘露聚糖的结构功能及其在结核病诊断中的应用[J]. 中国防痨杂志, 2022, 44(11): 1205-1212. DOI: 10.19982/j.issn.1000-6621.20220276 |
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| 作者姓名： | 唐明慧 李浩 |
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| 作者单位： | 中国农业大学动物医学院,北京 100193 |
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| 基金项目： | “十四五”国家重点研发计划(2021YFD1800405);国家自然科学基金面上项目(32070937);2115中国农业大学人才培育发展支持计划(00109029) |
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| 摘 要： | 结核病是由结核分枝杆菌复合群引发的人畜共患病，甘露糖帽修饰的脂阿拉伯甘露聚糖(mannose-capped-lipoarabinomannan，ManLAM)是结核分枝杆菌细胞壁上重要的成分，具有免疫调节作用，能够被固有细胞和适应性细胞所识别。作为结核病诊断的生物标记物，存在于体液的ManLAM具有较好的特异性，有区分...
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| 关 键 词： | 甘露聚糖类 分枝杆菌，结核 诊断 综述文献（主题） |
| 收稿时间： | 2022-07-25 |
Structure and function of lipoarabinomannan and its application in tuberculosis diagnosis |
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| Tang Minghui,Li Hao. Structure and function of lipoarabinomannan and its application in tuberculosis diagnosis[J]. The Journal of The Chinese Antituberculosis Association, 2022, 44(11): 1205-1212. DOI: 10.19982/j.issn.1000-6621.20220276 |
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| Authors: | Tang Minghui Li Hao |
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| Affiliation: | College of Veterinary Medicine, China Agricultural University, Beijng 100193, China |
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| Abstract: | Tuberculosis is a significant zoonosis caused by Mycobacterium tuberculosis complex. Mannose-capped-lipoarabinomannan (ManLAM), an essential glycolipid component of the cell wall, has immunomodulatory effects and is recognized by intrinsic cells and adaptive cells. ManLAM in body fluids is a biomarker with good specificity for the diagnosis of tuberculosis, and has the potential ability to differentiate the latent tuberculosis infection and active tuberculosis. It also plays a certain role in detecting tuberculosis patients whose sputum could not be obtained. This article mainly introduces the structure, biosynthesis, and the related antibodies of ManLAM and summarizes the research progress in the diagnosis of tuberculosis, in order to provide reference for the development of tuberculosis diagnostic technology. |
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| Keywords: | Mannans Mycobacterium tuberculosis Diagnosis Review literature as topic |
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