| 线粒体DNA在消化系恶性肿瘤发生发展中的作用机制研究进展 |
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| 引用本文： | 王凌霄,王颖佳,杨健,李耀平. 线粒体DNA在消化系恶性肿瘤发生发展中的作用机制研究进展[J]. 肿瘤防治研究, 2022, 49(8): 838-842. DOI: 10.3971/j.issn.1000-8578.2022.22.0542 |
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| 作者姓名： | 王凌霄 王颖佳 杨健 李耀平 |
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| 作者单位： | 030012 太原，山西医科大学第五临床医学院 |
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| 基金项目： | 山西省应用基础研究计划（201901D111431, 202103021224379）；山西省研究生教育创新计划（2021Y399） |
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| 摘 要： | 线粒体DNA（mt-DNA）是核外遗传信息的重要载体。近期研究结果显示，mt-DNA与多种恶性肿瘤的发生、转移密切相关，且可用于癌症的早期诊断和靶向治疗。因此进一步研究mt-DNA在消化系恶性肿瘤中的作用机制，对于筛选和鉴定肿瘤分子标志物用于抗肿瘤药物靶点、癌症诊断及预后分析均有重要的临床意义。本文对近年mt-DNA与消化系恶性肿瘤的潜在联系、临床应用及治疗靶点的研究进展进行综述。
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| 关 键 词： | mt-DNA 消化系恶性肿瘤 癌症 早期检测 临床转化应用 |
| 收稿时间： | 2022-05-19 |
Research Progress on Mechanism of Mitochondrial DNA in Occurrence and Development of Digestive System Malignant Tumors |
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| WANG Lingxiao,WANG Yingjia,YANG Jian,LI Yaoping. Research Progress on Mechanism of Mitochondrial DNA in Occurrence and Development of Digestive System Malignant Tumors[J]. Cancer Research on Prevention and Treatment, 2022, 49(8): 838-842. DOI: 10.3971/j.issn.1000-8578.2022.22.0542 |
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| Authors: | WANG Lingxiao WANG Yingjia YANG Jian LI Yaoping |
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| Affiliation: | The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China |
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| Abstract: | Mitochondrial DNA (mt-DNA) is an important carrier of extranuclear genetic information. Recent research results show that mt-DNA is closely related to the occurrence and metastasis of various malignant tumors, and can be used for early diagnosis and targeted therapy of cancer. Therefore, further research on the mechanism of mt-DNA in digestive system malignant tumors has important clinical significance for screening and identifying tumor molecular markers for anti-tumor drug targets, cancer diagnosis and prognosis analysis. This article reviews the research progress on the potential relationship, clinical application and therapeutictargets of mt-DNA and digestive system malignancies. |
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| Keywords: | mt-DNA Digestive system malignancies Cancer Early detection Clinical translation application |
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