人附睾蛋白4表达水平与子宫内膜癌淋巴结转移相关性的Meta分析

目的 系统评价子宫内膜癌（EC）中人附睾蛋白4（HE4）表达水平与淋巴结转移的相关性。方法 计算机搜索PubMed、Cochrane、Web of Science、CBM、CNKI和WanFang Data数据库中公开发表的有关HE4表达水平与子宫内膜癌淋巴结转移相关性的文献资料,检索时间自数据库建立截止2021年5月。按文献纳入和排除标准筛选文章,NOS病例对照研究质量评分量表进行文献质量评价,Stata12.0进行Meta分析,TSA进行样本量评价。结果 最终纳入25项符合标准的研究,共2 736例子宫内膜癌患者。Meta分析结果显示,HE4在EC淋巴结转移组的表达水平明显高于非转移组（SMD=1.58, 95%CI: 1.13~2.03）,且Meta回归分析显示HE4与EC淋巴结转移的相关性与年龄有关（P=0.009）。TSA分析表明纳入研究的总样本量满足要求。结论 HE4的表达水平与子宫内膜癌淋巴结转移存在相关性,此相关性可能受年龄影响,随着年龄的增加,此相关性减弱。

Meta-analysis of Relationship Between Expression Level of Human Epididymis Protein 4 and Lymph Node Metastasis in Endometrial Cancer

Objective To evaluate systematically the correlation between the expression level of human epididymis protein 4 (HE4) and lymph node metastasis of endometrial cancer (EC). Methods Computers were used to search for the literatures about the correlation between the expression level of HE4 and lymph node metastasis of EC in PubMed, Cochrane, Web of Science, CBM, CNKI, and Wanfang Database. The search time was from the database establishment to May 2021. Articles were screened in accordance with the inclusion and exclusion criteria, and the quality of literature was evaluated by Newcastle Ottawa scale. Stata12.0 was used to perform meta-analysis, and TSA was used to evaluate the sample size. Results A total of 2736 patients with EC were included in the 25 eligible studies. The results of meta-analysis showed that the expression level of HE4 in the EC-lymph-node metastasis group was significantly higher than that in the nonmetastasis group (SMD=1.58, 95%CI: 1.13-2.03), and meta-regression analysis revealed that the results were related to the average age of patients in each study. TSA analysis exhibited that the total sample size of the included studies met the requirements. Conclusion The expression level of HE4 is correlated with lymph node metastasis of EC, and this correlation may be affected by age, body mass index, and other factors. The correlation weakens with the increase in age.