| ceRNA调控网络在眼部疾病中的作用和机制研究进展 |
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| 引用本文： | 王斌,张燕.ceRNA调控网络在眼部疾病中的作用和机制研究进展[J].眼科新进展,2022,0(11):920-924. |
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| 作者姓名： | 王斌 张燕 |
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| 作者单位： | 022150 内蒙古自治区牙克石市，内蒙古林业总医院医学影像科（王斌）:150010 黑龙江省哈尔滨市，哈尔滨爱尔眼科医院 （张燕） |
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| 基金项目： | 内蒙古自治区自然科学基金项目(编号：2017MS0881)； |
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| 摘 要： | 近年来，非编码RNA在多种疾病发展进程中的作用日益显现。非编码RNA间可通过竞争性内源RNA(ceRNA)机制相互作用，参与重要的生物学过程。阐明非编码RNA参与的ceRNA调控网络在常见眼部疾病中的作用对于发现新的药物治疗靶点具有重要意义。本文概述ceRNA调控网络作为一类新的调控手段在糖尿病性视网膜病变、年龄相关性黄斑变性、青光眼和白内障等常见眼部疾病发生发展中的作用，以期为眼部疾病的临床诊疗提供理论依据。
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| 关 键 词： | 眼部疾病 ceRNA调控网络 非编码RNA |
Research progress in the effect of competing endogenous RNA regulatory network on ocular diseases and its mechanism |
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| WANG Bin,ZHANG Yan.Research progress in the effect of competing endogenous RNA regulatory network on ocular diseases and its mechanism[J].Recent Advances in Ophthalmology,2022,0(11):920-924. |
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| Authors: | WANG Bin ZHANG Yan |
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| Institution: | 1.Department of Medical Imaging,Inner Mongolia Forestry General Hospital,Yakeshi 022150,Inner Mongolia Autonomous Region，China 2.Haerbin Aier Eye Hospital,Haerbin 150010,Heilongjiang Province,China |
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| Abstract: | In recent years, an increasing number of studies have confirmed that non-coding RNAs play an important role in the progression of various human diseases. The non-coding RNAs interact with each other through the competing endogenous RNA (ceRNA) mechanism, thereby engaging in important biological processes. Exploring the role of the ceRNA regulatory network involving non-coding RNAs in ocular diseases can promote the discovery of new drug targets. This article reviews the role of the ceRNA regulatory network as a new regulatory pattern in common ocular diseases, such as diabetic retinopathy, age-related macular degeneration, glaucoma, and cataract, to provide a theoretical basis for clinical diagnosis and treatment of ocular diseases. |
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| Keywords: | ocular diseases competing endogenous RNA regulatory network non-coding RNA |
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