非小细胞肺癌根治术患者术后临床特征调查及预后影响因素分析

目的 分析行非小细胞肺癌根治术患者术后的临床特征及预后影响因素，为患者预后干预方案的制定提供理论依据。方法 选择2013年1月—2016年12月在湖州市中心医院进行非小细胞肺癌根治术的非小细胞肺癌患者514例作为研究对象。统计患者术后的临床特征，并采用多因素分析探究影响非小细胞肺癌根治术患者预后的因素。结果 514例非小细胞肺癌根治术患者临床特征如下：病变部位处于右肺292例(56.81%)、左肺222例(43.19%);组织学类型为腺癌284例(55.25%)、鳞癌206例(40.08%);305例(59.34%)患者术后出现远处器官转移；肿瘤分化程度为低分化286例(55.64%)、中/高分化228例(44.36%);临床TNM分期为Ⅰ～Ⅱ期418例(81.32%)、Ⅲ～Ⅳ期96例(18.68%)。多因素回归分析结果显示，肿瘤直径≥3 cm、术后远处器官转移、肿瘤低分化、临床分期Ⅲ～Ⅳ期、术后未化疗是非小细胞肺癌患者根治术后预后的影响因素(均P<0.05)。结论 肿瘤直径≥3 cm、术后远处器官转移、肿瘤低分化、临床分期Ⅲ～Ⅳ期、术后未化疗是非小细胞肺癌患者术后预后的独立影响...

Investigation of clinical characteristics and prognostic factors in patients with non-small cell lung cancer after radical resection

  Objective  To explore the clinical characteristics and prognostic factors of patients with non-small cell lung cancer after radical resection, and provide a theoretical basis for the formulation of prognostic intervention programs for patients.  Methods  A total of 514 patients who underwent radical resection of non-small cell lung cancer in Huzhou Central Hospital from January 2013 to December 2016 were selected as the research subjects. The postoperative clinical characteristics of the patients were counted, and the multivariate regression method was used to analyse the factors affecting the prognosis of patients with non-small cell lung cancer after radical resection.  Results  The clinical characteristics of 514 patients with non-small cell lung cancer after radical resection showed that the lesions were located in the right lung in 292 cases (56.81%) and in the left lung in 222 cases (43.19%). Histological types were mainly adenocarcinoma in 284 cases (55.25%) and squamous cell carcinoma in 206 cases (40.08%). Meanwhile, 305 cases (59.34%) had postoperative distant organ metastasis. Degree of tumour differentiation: 286 cases (55.64%) with low differentiation, 228 cases (44.36%) with moderate/high differentiation. Clinical TNM staging: 418 cases (81.32%) of stages Ⅰ-Ⅱ and 96 cases (18.68%) of stages Ⅲ-Ⅳ. The results of multivariate regression analysis showed that tumour diameter ≥ 3 cm, distant organ metastasis after the operation, medium/well-differentiated tumour, stages Ⅲ-Ⅳ, and no chemotherapy after operation were the prognostic influencing factors for patients with non-small cell lung cancer after radical resection (all P < 0.05).  Conclusion  Tumour diameter of ≥ 3 cm, distant organ metastasis after the operation, poorly differentiated tumour, stages Ⅲ-Ⅳ, and no postoperative chemotherapy are independent factors affecting the postoperative prognosis of patients with non-small cell lung cancer. Therefore, relevant prevention should be actively carried out in clinical practice to improve the quality of life of patients with non-small cell lung cancer after radical resection.