| 粪菌移植治疗孤独症谱系障碍的研究进展 |
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| 引用本文： | 李晓燕,徐新杰,罗欣,尤欣. 粪菌移植治疗孤独症谱系障碍的研究进展[J]. 协和医学杂志, 2022, 13(5): 753-759. DOI: 10.12290/xhyxzz.2022-0301 |
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| 作者姓名： | 李晓燕 徐新杰 罗欣 尤欣 |
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| 作者单位： | 1.中国医学科学院北京协和医院风湿免疫科，北京 100730 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程2017-I2M-3-017中国医学科学院中央级公益性科研院所基本科研业务费专项资金2019XK320030 |
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| 摘 要： | 孤独症谱系障碍(autism spectrum disorder, ASD)是发病于儿童早期的神经发育障碍性疾病，目前尚无有效的治愈手段。其发病率近年来明显上升，给患者家庭和社会带来了沉重负担。ASD患者多存在胃肠道症状和肠道菌群失衡，研究发现ASD患者的胃肠道功能障碍与肠道菌群结构变化密切相关，且通过粪菌移植可显著改善ASD相关症状。本文通过总结粪菌移植治疗ASD的最新研究进展，以期为ASD的治疗提供新思路。
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| 关 键 词： | 孤独症 粪菌移植 发育障碍 肠道菌群 |
| 收稿时间： | 2022-05-30 |
Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation |
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| Affiliation: | 1.Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China2.Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China |
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| Abstract: | Autism spectrum disorder (ASD), a neurodevelopmental disorder during early childhood, currently has no effective treatment. The prevalence of ASD has been increasing, which brings a heavy burden to the family of the patients and the society. Children with ASD are accompanied by gastrointestinal symptoms and have an imbalance of intestinal microbiota. Fecal microbiota transplantation (FMT) can improve autism-related symptoms in children with ASD. This review aims to summarize the research progress of FMT for treating ASD to provide a novel strategy for this untreatable disease. |
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