| 毛细胞白血病的治疗新进展 |
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| 引用本文： | 李转丽1,2,3,王 莹1,2,李小燕1,2,白 海1,2. 毛细胞白血病的治疗新进展[J]. 现代肿瘤医学, 2022, 0(22): 4204-4207. DOI: 10.3969/j.issn.1672-4992.2022.22.037 |
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| 作者姓名： | 李转丽1 2 3 王 莹1 2 李小燕1 2 白 海1 2 |
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| 作者单位： | 1.甘肃中医药大学第一临床医学院，甘肃 兰州 730000;2.中国人民解放军联勤保障部队第九四〇医院血液科，甘肃 兰州 730050;3.甘肃省干细胞与基因药物重点实验室，甘肃 兰州 730050 |
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| 基金项目： | 甘肃省科技重大专项计划项目（编号:1102FKDA005） |
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| 摘 要： | 毛细胞白血病(hairy cell leukemia,HCL)是一种罕见的B细胞肿瘤性疾病,主要是由BRAF V600E突变引起。常规的治疗药物是克拉屈滨、喷司他汀及干扰素,疗效显著,但50%的HCL患者仍会复发,急需新的药物来联合治疗。近年来,关于HCL的临床试验层出不穷,给HCL的治疗带来新的希望。因此,本文就HCL最新的治疗进展作一综述。
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| 关 键 词： | 毛细胞白血病 治疗 BRAF抑制剂 moxetumomab pasudotox |
New advances in the treatment of hairy cell leukemia |
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| LI Zhuanli1,2,' target='_blank'>3,WANG Ying1,' target='_blank'>2,LI Xiaoyan1,' target='_blank'>2,BAI Hai1,' target='_blank'>2. New advances in the treatment of hairy cell leukemia[J]. Journal of Modern Oncology, 2022, 0(22): 4204-4207. DOI: 10.3969/j.issn.1672-4992.2022.22.037 |
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| Authors: | LI Zhuanli1 2 ' target='_blank'>3 WANG Ying1 ' target='_blank'>2 LI Xiaoyan1 ' target='_blank'>2 BAI Hai1 ' target='_blank'>2 |
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| Affiliation: | 1.The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;2.Department of Hematology,the 940th Hospital of Joint Logistic Support Force of PLA,Gansu Lanzhou 730050,China;3.Key Laboratory of Stem Cells and Gene Medicine of Gansu Province,Gansu Lanzhou 730050,China. |
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| Abstract: | Hairy cell leukemia（HCL）is a rare B-cell neoplastic disease,mainly caused by BRAF V600E mutation.The conventional treatment drugs are clabine,pentastatin and interferon and the effect is remarkable.However,the 50% of HCL patients still relapse.Therefore,new drugs are urgently needed for combination therapy.In recent years,clinical trials on HCL emerge in an endless stream,bringing new hope for HCL treatment.Hence,this article reviews the recent advances in the treatment of HCL. |
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| Keywords: | hairy cell leukemia treatment BRAF inhibitor moxetumomab pasudotox |
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