急性原发性房角关闭患者昼夜节律状况的研究

目的 研究急性原发性房角关闭(APAC)患者急性发作前的昼夜节律，调查患者在发作前是否存在昼夜节律紊乱，探讨昼夜节律紊乱与APAC的因果关系。方法 收集2016年2月至2018年1月中山大学中山眼科中心海南眼科医院APAC患者46例(APAC组),可疑原发性房角关闭患者(PACS组)30例和健康对照人群(NC组)40例，均为单眼。所有受试者均接受匹斯堡睡眠质量指数(PSQI)问卷调查，利用相关参数反应昼夜节律，比较3组受试者的睡眠状况。结果 在PSQI总得分参数中，APAC组和PACS组患者总得分均>7分，说明均存在睡眠障碍，且与PACS组和NC组比较，APAC组患者PSQI总得分差异均有统计学意义(均为P<0.05)。PACS组与NC组受试者的PSQI总得分差异无统计学意义(P>0.05)。在睡眠质量参数中，APAC组与NC组受试者差异有统计学意义(P<0.05),与PACS组比较，NC组和APAC组受试者差异均无统计学意义(均为P>0.05)。与PACS组和NC组比较，APAC组患者睡眠时间、睡眠效率、依赖睡眠药物、睡眠紊乱以及白天困倦情况差异均有统计...

Circadian rhythm status in patients with acute primary angle-closure

Objective　To investigate the circadian rhythm of patients with acute primary angle-closure (APAC) before the acute attack, and the causal relationship between circadian rhythm disorder and APAC. Methods　From February 2016 to January 2018, 46 APAC patients (APAC group), 30 primary angle-closure suspect (PACS) patients (PACS group), and 40 healthy controls (normal control, NC group) were collected from Hainan Eye Hospital, Zhongshan Eye Center, Sun Yat-sen University. Single eyes of all patients were included in this study. All patients were investigated by Pittsburgh Sleep Quality Index (PSQI) questionnaire. The circadian rhythm was reflected with relevant parameters. The sleep quality of patients in the three groups was compared. Results　The PSQI scores of the APAC group and the PACS group were higher than 7 points, indicating that patients in these two groups had sleep disorders. There were statistically significant differences in the PSQI score between the APAC group and the PACS group, the APAC group and the NC group (both P<0.05). However, there was no significant difference between the PACS group and the NC group (P>0.05). Compared with the NC group, the APAC group showed a statistically significant difference in sleep quality (P<0.05). However, there was no significant difference in sleep quality between the PACS and NC groups, PACS and APAC groups (both P>0.05).In addition, compared with the PACS group and the NC group, the APAC group showed statistically significant differences in sleep duration, sleep efficiency, dependence on sleep drugs, sleep disorder, and daytime sleepiness (all P<0.05). There were statistically significant differences in sleep duration and sleep disorder between the PACS group and the NC group (both P<0.05). Conclusion　Circadian rhythm disorder may be one of the causes of acute onset of primary angle closure. It is expected that the early intervention of circadian rhythm disorder can reduce the acute onset of primary angle closure, providing a new idea for lowering the disability and blindness caused by glaucoma.