| 抗结核药物贝达喹啉的耐药情况及其耐药机制研究进展 |
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| 引用本文： | 姚蓉,陆宇. 抗结核药物贝达喹啉的耐药情况及其耐药机制研究进展[J]. 中国防痨杂志, 2022, 44(9): 973-977. DOI: 10.19982/j.issn.1000-6621.20220122 |
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| 作者姓名： | 姚蓉 陆宇 |
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| 作者单位： | 首都医科大学附属北京胸科医院/耐药结核病研究北京市重点实验室/北京市结核病胸部肿瘤研究所药物学研究室,北京101149 |
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| 基金项目： | 国家自然科学基金(82173862);北京市医院管理中心临床医学发展专项(ZYLX202123);北京市医院管理中心登峰人才项目(DFL20221402) |
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| 摘 要： | 随着耐多药结核病(multidrug-resistant tuberculosis, MDR-TB)和广泛耐药结核病(extensively drug-resistant tuberculosis, XDR-TB)菌株的增多，结核分枝杆菌(Mycobacterium tuberculosis,MTB)的耐药性成为全球亟待解决的问题。贝达喹啉(bedaquiline, Bdq)作为近50年来首个明确用于MDR-TB治疗的新药，其耐药问题受到逐步关注。笔者对Bdq的耐药特征和耐药基因突变等研究进展进行综述，旨在更好指导临床用药，提高患者的治疗成功率，减少耐药的发生。
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| 关 键 词： | 结核 抗药性 贝达喹啉 综述文献(主题) |
| 收稿时间： | 2022-04-12 |
Research progress on the drug resistance and mechanism of the anti-tuberculosis drug bedaquiline |
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| Yao Rong,Lu Yu. Research progress on the drug resistance and mechanism of the anti-tuberculosis drug bedaquiline[J]. The Journal of The Chinese Antituberculosis Association, 2022, 44(9): 973-977. DOI: 10.19982/j.issn.1000-6621.20220122 |
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| Authors: | Yao Rong Lu Yu |
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| Affiliation: | Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149,China |
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| Abstract: | With the increase of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) strains, drug resistance of Mycobacterium tuberculosis (MTB) has become an urgent problem worldwide. Bedaquiline (Bdq) is the first new drug specifically in the treatment of MDR-TB in recent 50 years, and its drug resistance been gradually concerned. The research progress of drug resistance characteristics and drug resistance gene mutations of Bdq were reviewed, in order to better guide clinical medication, improve the success rate of treatment, and reduce the occurrence of drug resistance. |
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| Keywords: | Tuberculosis Drug resistance Bedaquiline Review literature as topic |
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