| PBPK模型在抗感染药物研发及临床评价中的应用 |
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| 引用本文： | 董柳含,许小菊王瑾蔡芸. PBPK模型在抗感染药物研发及临床评价中的应用[J]. 中国抗生素杂志, 2022, 47(10): 1013-1019 |
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| 作者姓名： | 董柳含 许小菊王瑾蔡芸 |
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| 摘 要： | 摘要：生理药动学( physiologically based pharmacokinetic,PBPK) 模型是一种模拟药物在人或动物体内吸收、分布、代谢和排泄过程的数学模型,集成了药物的理化和系统(生理)信息,能描述药物在靶组织器官中的经时变化,用于药物研究的各个阶段。本文将综述PBPK模型在抗感染药物研发及临床评价中的应用,为抗感染药物研发及临床合理应用提供参考。
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| 关 键 词： | 生理药动学模型 抗感染药物 新药研发 合理用药 |
Applications of PBPK model in the development and clinical evaluation of anti-infective drugs |
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| Dong Liu-han,Xu Xiao-ju,Wang Jin,Cai Yun. Applications of PBPK model in the development and clinical evaluation of anti-infective drugs[J]. Chinese Journal of Antibiotics, 2022, 47(10): 1013-1019 |
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| Authors: | Dong Liu-han Xu Xiao-ju Wang Jin Cai Yun |
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| Abstract: | Abstract Used in the different stages of drug research, the physiologically based pharmacokinetic (PBPK)model is a mathematical model that simulates the absorption, distribution, metabolism and excretion of drugs inhumans or animals, which can describe the changes in the target tissues and organs over time. This article will reviewthe applications of the PBPK model in the development and clinical evaluation of anti-infective drugs, and providereferences for the development of anti-infective drugs and rational clinical application. |
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| Keywords: | Physiologically based pharmacokinetic model Anti-infective drug Drug development Rational drug-use |
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