| 低剂量辐射生物效应的研究进展 |
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| 引用本文： | 魏新锋,王蕊,衣峻萱,王铭蔚,金顺子. 低剂量辐射生物效应的研究进展[J]. 中国辐射卫生, 2022, 31(1): 113-118,128. DOI: 10.13491/j.issn.1004-714X.2022.01.020 |
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| 作者姓名： | 魏新锋 王蕊 衣峻萱 王铭蔚 金顺子 |
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| 作者单位： | 吉林大学公共卫生学院，国家卫健委放射生物学重点实验室，吉林 长春 130021 |
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| 基金项目： | 国家自然科学基金（81872550） |
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| 摘 要： | 低剂量辐射(low-dose radiation,LDR)生物效应仍然是放射生物学领域的研究热点.随着研究的深入,对LDR产生的各种生物效应及其机制不断完善.越来越多的证据表明,LDR诱导的生物效应和高剂量辐射不同,这些研究对"线性无阈"模型提出质疑.本文从LDR诱导的旁效应、兴奋效应、适应性反应以及低剂量辐射超敏感性...
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| 关 键 词： | 低剂量辐射 旁效应 兴奋效应 适应性反应 超敏感性 |
| 收稿时间： | 2021-08-21 |
Research progress in biological effects of low-dose radiation |
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| WEI Xinfeng,WANG Rui,YI Junxuan,WANG Mingwei,JIN Shunzi. Research progress in biological effects of low-dose radiation[J]. Chinese Journal of Radiological Health, 2022, 31(1): 113-118,128. DOI: 10.13491/j.issn.1004-714X.2022.01.020 |
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| Authors: | WEI Xinfeng WANG Rui YI Junxuan WANG Mingwei JIN Shunzi |
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| Affiliation: | Key Laboratory of Radiobiology, National Health Commission, School of Public Health, Jilin University, Changchun 130021 China |
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| Abstract: | The biological effects of low-dose radiation (LDR) are still a research hotspot in the field of radiobiology. As research deepens on LDR-induced biological effects and the mechanisms, growing evidence shows that LDR produces distinct biological effects from high-dose radiation, which questions the linear non-threshold model. This article reviews LDR-induced bystander effect, hormesis, adaptive response, and hyper-radiosensitivity, as well as the mechanisms, in order to provide a reference for the transformation of basic research on LDR-related biological effects to clinical application. |
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| Keywords: | Low-dose radiation Hormesis Excitatory effect Adaptive response Hyper-radiosensitivity |
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